Trop2靶向药物在肿瘤治疗中的前景

The Prospect of Trop2-Targeting Drugs in Tumor Therapy

Trop2又被称为肿瘤相关钙信号转导因子2(tumor associated calcium signal transducer 2)是一种细胞表面糖蛋白,在正常组织中低表达或不表达,但在多种肿瘤(如胰腺癌、结肠癌和乳腺癌等)中高表达,其高表达与肿瘤预后密切相关。Trop2在肿瘤细胞自我更新、增殖、入侵和转化中发挥重要作用,是临床检测肿瘤恶性程度的分子标记和肿瘤治疗的潜在靶点。目前已有多个以Trop2为靶点的药物进入了临床试验研究阶段。该文就Trop2的结构、生理学功能、与肿瘤的关系及其相关药物研发等方面进行综述。

Trop2 is also called tumor-associated calcium signal transducer 2.It is a type of cell surface glycoprotein that is lowly or not expressed in normal tissues,but is highly expressed in a variety of tumors,such as pancreatic cancer,colon cancer and breast cancer.Trop2 plays an important role in the self-renewal,proliferation,invasion and transformation of tumor cells,and it is a molecular marker for clinical detection of tumor malignancy and a potential target for tumor therapy.This paper reviews the structure,physiological function,relationship between Trop2 and tumors,and its related drug development.