脂肪组织衍生物在修复再生领域的应用研究

Application of Adipose Tissue Derivatives in the Field of Repair and Regeneration

自体脂肪组织含量丰富、获取方便且组织相容性好,作为一种软组织填充材料显示出良好的优势。除了大量成熟的脂肪细胞,脂肪组织还富含干细胞、免疫细胞和血管相关细胞(统称为血管基质成分)。这些血管基质成分可以分泌大量的生物活性因子,参与免疫调节和损伤修复,从而为细胞疗法和修复重建提供新的思路。但由于脂肪组织成分复杂,质量评价标准不详,取得的疗效也不稳定,因此脂肪组织衍生物在广泛应用的同时也备受争议。该文就脂肪组织衍生物在整形修复领域的临床前研究和临床研究进行综述,以期为脂肪组织衍生物的临床应用提供一定的指导意义。

Adipose tissue can be easily obtained in large quantities and has shown promise in the repairation of soft-tissue defects.Except of adipocytes,adipose tissue provides an abundant source of SVF(stromal vascular fraction)cells including stem cells,immune cells and blood-vessel related cells.These SVF cells secrete various cytokines and mediate immune regulation and injury repair,providing novel ideas for cell therapy and repair and reconstruction.However,it’s controversial to be widely used,due to the complex composition of adipose tissue,unclear quality evaluation criteria,and unstable efficacy.This review summarizes the preclinical and clinical studies of adipose tissue derivatives in the field of plastic repair to provide some guidance for the clinical application of adipose tissue derivatives.