胺和亚胺氮甲基化反应的研究进展

Recent Advances and Applications in N-Methylation of Amines and Imines

胺类化合物的氮甲基化反应是一类重要的有机合成反应,在实验室研究与工业合成中具有重要的应用.传统的氮甲基化反应会涉及使用易燃易爆且剧毒的物质,而新兴的制备方案很好的解决了这方面的问题,更加符合绿色化学的标准和环境保护的需求.对于氮甲基化反应,C1碳源的选择直接决定了该反应的催化剂、反应条件、反应机理及底物范围等.将从不同碳源的角度介绍近年来胺和亚胺氮甲基化反应的研究进展,并对其作用机理进行相关阐述.

N-Methylation of amines and imines is one of the most important reactions for C—N bond formation.It is widely utilized for both laboratary research and industrial applications.Traditional methylation reactions involve the use of flammable,explosive and toxic starting materials.In contrast,newly developed methods have overcome this point and provide a mild strategy.In this transformation,C1 carbon source for the methyl group is important which determines the type of catalyst,reaction conditions and substrate scope.Herein,the research progress for the N-methylation of amines and imines is summarized based on different C1 carbon source.