百令胶囊联合左氧氟沙星治疗耐多药肺结核患者的临床疗效研究

Clinical Efficacy of Bailing Capsule Combined with Levofloxacin on Multidrug-Resistant Tuberculosis

目的:观察百令胶囊联合左氧氟沙星治疗耐多药肺结核的临床疗效。方法:选取本院2019年1月至2019年12月收治的180例复治涂片阳性的耐多药肺结核患者,按照随机平行分组法将患者分为两组,每组各90例。对照组复治方案为3HRZE方案+左氧氟沙星治疗,观察组在上述治疗方案的基础上加用百令胶囊,比较两组患者12个月后的临床疗效、痰检阴转率、病灶吸收率、空洞闭合率、免疫功能(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)及监测用药期间不良反应。结果:与治疗前比较,两组治疗后总有效率对照组为78.9%,观察组为93.3%;痰检阴转率对照组为53.3%,观察组为76.7%;病灶吸收率对照组为84.4%,观察组为95.5%;空洞闭合率对照组为75.6%,观察组为92.2%,观察组均明显优于对照组(P<0.05);与治疗前比较,两组治疗后CD3^+、CD4^+、CD4^+/CD8^+水平均明显升高,CD8^+水平明显下降(P<0.05或P<0.01)。治疗后与对照组比较,观察组治疗总有效率、痰检阴转率、病灶吸收率、空洞闭合率均明显高于对照组(P<0.05);观察组CD3^+、CD4^+、CD4^+/CD8^+水平均明显增高(P<0.05);观察组的不良反应总体发生率明显低于对照组(P<0.05)。结论:耐多药肺结核的患者应用百令胶囊联合左氧氟沙星治疗具有良好的治疗效果,可明显改善临床症状,促进肺部空洞闭合,调节患者免疫功能,具有较高的临床应用价值。

Objective:To observe the clinical efficacy of Bailing capsule combined with levofloxacin in the treatment of multidrug-resistant tuberculosis.Methods:180 patients with MDR-TB(positive in slide)treated in our hospital from January 2019 to December 2019 were selected,and were divided into two groups according to the randomized parallel grouping method,90 patients in each group.The patients in the control group were treated with 3 HRZE and levofloxacin,those in the observation group were supplemented with Bailing capsules on the basis of the above treatment regimen.The clinical efficacy,sputum conversion rate,lesion absorption rate,cavity closure rate,and the immune function(CD3^+,CD4^+,CD8^+,CD4^+/CD8^+)in two groups were compared,and adverse reactions during medication was monitored.Results:Compared with before treatment,the total effective rate in the control group and observation group after treatment was 78.9%and 93.3%,respectively.The sputum negative conversion rates were 53.3%(the control group)and 76.7%(the observation group),the lesion absorption rates were 84.4%(the control group)and 95.5%(the observation group),the cavity closure rates were 75.6%(the control group)and 92.2%(the observation group),which suggested the treatment in the observation group had more advantage(P<0.05).After treatment,the levels of CD3^+,CD4^+,CD4^+/CD8^+were increased in both groups,and the CD8^+levels were decreased(P<0.05 or P<0.01).Compared with the control group after treatment,the total effective rate of treatment,the sputum negative conversion rate,the lesion absorption rate,and the cavity closure rate in the observation group were increased(P<0.05).the levels of CD3^+,CD4^+,CD4^+/CD8^+in the observation group were significantly increased(P<0.05),the overall incidence of adverse reactions in the observation group was decreased(P<0.05).Conclusion:Bailing capsules combined with levofloxacin has the good therapeutic effect in patients with multidrug-resistant tuberculosis.It can significantly improve clinical symptoms,promote the closure of lung cavities,and regulate the immune function of patients,which has high clinical application value.