大黄䗪虫丸抗肿瘤作用机制及临床应用研究进展

Research progress of anti-tumor mechanism and clinical application of Dahuang-Zhechong Pill

综述《金匮要略》大黄䗪虫丸作用机制及临床应用研究相关文献,发现大黄䗪虫丸主要通过抑制细胞增殖、诱导细胞凋亡、调节免疫功能、抑制肿瘤血管生成、影响肿瘤细胞转移、逆转细胞耐药等途径实现抗肿瘤作用,多用于治疗肝癌、胃癌、食管癌、肺癌等恶性肿瘤;应进一步明确其抗肿瘤机制、优势剂型、优势瘤种,并对其治疗剂量及不良反应发生剂量进一步规范。

This paper reviewed the mechanism and clinical application of Dahuang-Zhezhong Pill in Jin Gui Yao Lue.It was found that the anti-tumor effect of Dahuang-Zhezhong Pill was mainly achieved by inhibiting cell proliferation,inducing cell apoptosis,regulating immune function,inhibiting tumor angiogenesis,affecting tumor cell metastasis,and reversing cell resistance.It was used in the treatment of liver cancer,gastric cancer,esophageal cancer,lung cancer and other malignant tumors.Therefore,we should clarify the anti-tumor mechanism,the dominant dosage,the dominant tumor species of Dahuang-Zhezhong Pill,and standardize the dosage of treatment and adverse reactions.