摘要
长期摄入大量乙醇导致肠源性内毒素血症,活性氧、高浓度的三磷酸腺苷及尿酸激活焦亡系统,进而通过切割Gasdermin-D打孔机制导致肝细胞死亡,同时伴有白细胞介素-1β、白细胞介素-18等炎性因子的释放。这一系列的过程激活免疫系统,介导级联炎症反应,促进酒精性肝病从脂肪变性到炎症、纤维化的进展。
Long-term intake of large amounts of ethanol leads to enterogenous endotoxemia.Reactive oxygen species,high concentrations of adenosine triphosphate and uric acid activate the pyroptosis system,which then cleaves the pore formation mechanism of gasdermin-D,leading to the death of liver cells,accompanied by the release of interleukin-1β,interleukin-18,and other inflammatory factors.This series of processes activates the immune system,mediates a cascade of inflammation,and promotes the development of alcoholic liver disease from steatosis to inflammation and fibrosis.
作者
邓玉婷
魏峰
周俊英
Deng Yuting;Wei Feng;Zhou Junying(Department of Infectious Disease,the Third Hospital of Hebei Medical University,Shijiazhuang 050051,China;Fifth Hospital of Shijiazhuang,Shijiazhuang 050021,China)
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2020年第8期715-718,共4页
Chinese Journal of Hepatology
基金
河北省自然科学基金(H2017206304)
政府资助临床医学优秀人才培养项目基金(2017)。
关键词
内毒素血症
炎症
因子
酒精性肝病
焦亡
Endotoxemia
Inflammation
Factors
Alcoholic liver disease
Pyroptosis