摘要
Objective:To evaluate the effects of Zhumeria majdae essential oil(ZMEO)on morphine dependence and tolerance in mice.Methods:ZMEO(10,20,and 40 mg/kg)and clonidine(0.1 mg/kg)as the positive control were injected intraperitoneally(i.p.).The effect of ZMEO and clonidine on the dependence were evaluated by counting the number of jumps induced by naloxone(5 mg/kg)while the tolerance was evaluated by the tail-flick test.Results:ZMEO at the dose of 10 mg/kg during the development period led to a significant inhibition of morphine tolerance(P<0.01),while it led to reduced morphine dependence with the doses of 20 and 40 mg/kg.ZMEO at two dose levels of 20 and 40 mg/kg indicated significant antinociceptive activity(P<0.01),and significantly reduced the withdrawal signs(number of jumps)of mice(P<0.01).Conclusions:ZMEO had significant effects on morphine tolerance and dependence.The linalool rich essential oil of Zmajdae plays a major role in the reduction of tolerance and dependence induced by morphine.
