高尿酸血症与心血管代谢指数在非肥胖人群中的相关性研究

Correlation between hyperuricemia and cardiovascular metabolic index in non-obese people

目的探讨心血管代谢指数(CMI)在非肥胖中国人群中与高尿酸血症(HUA)的相关性。方法应用横断面研究方法,以2014年1月至2017年12月来自江苏省靖江市人民医院、空军杭州特勤疗养中心和海军军医大学附属长海医院接受健康体检的73150名非肥胖人群为研究对象。收集了其人体测量学、血脂、尿酸等体检指标,由腰身比(WHtR)、TG及HDL-C计算CMI的值。通过多因素Logistic回归模型分析了CMI与HUA的相关性。结果39443名非肥胖女性中,有5825例HUA,其患病率为14.77%;33707名非肥胖男性中,有7720例HUA,其患病率为22.90%。Logistic回归分析显示女性CMI最高四分位的OR值95%CI为6.311(5.734,6.947),男性为6.785(6.092,7.557),P均<0.01;而传统的肥胖指标腰臀比和WHtR未显示出与HUA显著相关性。结论CMI有望成为非肥胖中国人群预防和管理HUA和痛风的内脏肥胖监测指标。

Objective This study explored the correlation between Cardiovascular metabolic index(CMI)and hyperuricemia(HUA)in non-obese Chinese population.Methods 73150 non-obese people who received routine physical examination between January 2014 to December 2017 were included in this cross-sectional study(from Jingjiang People's Hospital of Jiangsu Province,Hangzhou Aeronautical Sanatorium of Chinese Air Force,and Shanghai Changhai Hospital).The anthropometric indexes,lipid parameters including triglycerides,and high-density lipoprotein cholesterol,uric acid,and other clinical parameters were collected,and the CMI values were calculated from the waist-to-body ratio(WHtR).The correlation between CMI and HUA was analyzed by Logistic regression model.Results Among 39443 non-obese women,5825 patients were HUAs with a prevalence rate of 14.7%;among 33707 non-obese men,7720 were HUAs with a prevalence rate of 22.9%.HUA had no significant association with Waist-to-Hip Ratio(WHR)and WHtR,but only with CMI.The highest quartile of women in CMI was 6.311(5.734,6.947)and 6.785(6.092,7.557)in male,P<0.01.Conclusion CMI is significantly associated with HUA in non-obese Chinese population and is expected to become a new monitoring parameter for the prevention and management of HUA and gout.