肝癌细胞上皮-间质转化及其信号通路研究进展

Epithelial-mesenchymal Transition and Signaling Pathways in Hepatocellular Carcinoma

肝细胞癌(HCC)是最常见的侵袭性恶性肿瘤之一,也是全球癌症相关死亡的第三大原因。肝细胞肿瘤主要由肝腺瘤,肝细胞癌(HCC)和前病变组成。良性肿瘤如肝腺瘤虽然通常不致命,但可能在引起恶性转化方面引起显着的临床挑战。由于肝炎病因而导致的HCC是全球癌症死亡的主要原因之一。尽管近年来关于HCC的知识呈指数级增长,但HCC的治疗和预防仍然是一个巨大的挑战,需要对肝癌发生的分子机制有深入的了解。最新研究发现EMT在HCC进展中发挥重要作用。总结了EMT在肝癌的作用及其相关信号分子机制,这些研究在诊断、预后和/或治疗方面具有潜在的临床意义。

Hepatocellular carcinoma(HCC)is one of the most common,aggressive malignancies and the third leading cause of cancer-related mortality worldwide.Hepatocellular neoplasms mainly consist of hepatic adenoma,HCC and precuror lesions.Benign tumors such as hepatic adenoma,while usually not deadly,may cause significant clinical challenges including maligant transformation.HCC due to vaiousetiologies is one of the major leading causes of cancer death worldwide.Although knowledge about HCC is expanding exponentially in recent years,treatment and prevention of HCC is still a big challenge,and requires our thorough understanding of the molecular mechanisms of hepatocarci no-genesis.In this review,we summarized the role of EMT in liver cancer and its related signaling molecular mechanisms that have potential clinical implication in diagnosis,prognostication and/or therapy.