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七氟醚对子痫前期产妇TNF-α、IL-6表达的影响研究 被引量:3

Study on the effect of sevoflurane on expression of TNF-α,IL-6 in preeclampsia pregnancies
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摘要 目的观察七氟醚对子痫前期(PE)产妇外周血和胎盘组织中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)表达的影响。方法选取30例拟行择期剖宫产的PE产妇,分为硬膜外麻醉组(E组)和硬膜外麻醉+七氟醚麻醉组(E+S组),每组15例。采用ELISA检测术前、胎儿娩出后母体外周血中TNF-α、IL-6水平,并分离胎盘组织滋养层细胞,采用免疫组织化学(IHC)检测滋养层细胞中TNF-α、IL-6的表达情况,ELISA检测滋养层细胞培养基中TNF-α、IL-6水平。结果E组胎儿娩出后母体外周血IL-6水平高于术前,E+S组胎儿娩出后母体外周血和胎盘组织TNF-α、IL-6水平明显低于E组,差异有统计学意义(P<0.05)。结论七氟醚可降低PE产妇外周血与胎盘组织中TNF-α、IL-6的表达水平。 Objective To investigate the effect of sevoflurane on expression of TNF-αand IL-6 in the peripheral blood and placental tissues of preeclampsia(PE)pregnancies.Methods A total of 30 PE pregnancies who were scheduled for cesarean section were selected and divided into the epidural anesthesia group(group E)and the epidural plus sevoflurane anesthesia group(group E+S),with 15 cases in each group.ELISA was used to detect tumor necrosis factors-α(TNF-α)and interleukin-6(IL-6)concentrations in maternal peripheral blood before and after fetal delivery,then separated the placental tissue trophoblast cells,immunohistochemistry(IHC)was used to detect the expression of TNF-αand IL-6 in trophoblast cells,while the expression of TNF-αand IL-6 in trophoblast cell culture medium was detected by ELISA.Results The concentration of IL-6 in maternal peripheral blood after delivery of the fetus in group E was higher than that before operation.The concentrations of TNF-αand IL-6 in maternal peripheral blood and placenta tissue after fetus delivery in group E+S were significantly lower than those in group E(P<0.05).Conclusion Sevoflurane could reduce the expression of TNF-αand IL-6 in peripheral blood and placental tissue of PE pregnancies.
作者 贾杰 黄彩霞 洪淑贞 韩宝义 莫力 JIA Jie;HUANG Caixia;HONG Shuzhen;HAN Baoyi;MO Li(Department of Anesthesiology,Guangdong Women and Children Hospital,Guangzhou,Guangdong 510010,China;Department of Obstetrics,Guangdong Women and Children Hospital,Guangzhou,Guangdong 510010,China)
出处 《重庆医学》 CAS 2020年第16期2657-2662,共6页 Chongqing medicine
基金 广东省科技计划项目(2017A040405033)。
关键词 七氟醚 肿瘤坏死因子Α 白细胞介素6 先兆子痫 剖宫产术 sevoflurane tumor necrosis factor-alpha interleukin-6 pre-eclampsia cesarean section
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