PTX3在开颅术后颅内感染中的诊断价值研究

Study on the diagnosis value of PTX3 for intracranial infection after craniotomy

目的探讨正五聚蛋白3(PTX3)在神经外科开颅术后颅内感染早期诊断中的应用价值。方法选取开颅术后并发颅内感染的48例患者作为感染组,选取同期行开颅手术但无颅内感染的62例患者作为未感染组。比较两组血白细胞、C反应蛋白(CRP)和PTX3水平,同时采用受试者工作特征(ROC)曲线分析白细胞、CRP和PTX3诊断颅内感染的价值,探讨PTX3诊断颅内感染的效能。结果感染组白细胞、CRP和PTX3水平高于对照组,差异有统计学意义(P<0.05)。ROC曲线分析结果表明,白细胞、CRP和PTX3的ROC曲线下面积(AUC)分别为0.686、0.812和0.901(P<0.05),灵敏度分别为68.9%、83.3%和91.7%,特异度分别为59.7%、79.0%和87.1%,PTX3综合诊断效能最高。结论PTX3在开颅术后颅内感染的早期诊断中具有重要参考价值。

Objective To explore the predictive value of pentraxin 3(PTX3)in early diagnosis of intracranial infection after neurosurgical craniotomy.Methods A total of 48 patients with intracranial infection after craniotomy in hospital were chosen as the infection group,and 62 patients who underwent craniotomy without intracranial infection during the same period were selected as the non-infection group.Leukocytes,C-reactive protein(CRP),PTX3 were compared between the two groups,and the receiver operating characteristic(ROC)curve was used to analyze the predictive value of leukocytes,CRP and PTX3 in the diagnosis of intracranial infection,and the efficacy of PTX3 in the diagnosis of intracranial infection was discussed.Results After operation,the levels of leukocytes,CRP and PTX3 in the infection group were significantly higher than those in the non-infection group(P<0.05).The areas under of ROC curve(AUC)for leukocytes,CRP and PTX3 was 0.686,0.812 and 0.901,respectively(P<0.05).The sensitivity of those indexes above was 68.9%,83.3%and 91.7%,respectively.The specificity of those indexes was 59.7%,79.0%and 87.1%,respectively.The ROC analysis showed that the predictive value of PTX3 was higher than any index.Conclusion PTX3 has great clinical value in diagnosis of intracranial infection after craniotomy.