NUDT15基因多态性与巯嘌呤药物耐受性关系的研究进展

Research progress on relationship between NUDT15 gene polymorphism and mercaptopurine drug tolerance

巯嘌呤是治疗急性淋巴细胞白血病、炎症性肠病的首选药物,巯嘌呤药物在人体内代谢产物可干扰核苷酸代谢和蛋白质合成。患者因药物不良反应尤其是白细胞减少,不得不减量或停止使用巯嘌呤药物。近年来研究发现,亚洲人群中核苷酸焦磷酸酶15(NUDT15)基因突变与巯嘌呤药物耐受性所致的白细胞减少等不良反应有密切联系。该文对近年来国内外有关NUDT15基因多态性与巯嘌呤药物耐受性的最新研究进展进行综述。

Mercaptopurine is the drug of choice for the treatment of acute lymphoblastic leukemia(ALL)and inflammatory bowel disease(IBD).The metabolites of mercaptopurine drugs in human body can interfere with nucleotide metabolism and protein synthesis.Patients have to reduce or stop using mercaptopurine drugs due to adverse drug reactions,especially leukopenia.Recent studies have found that mutations in the NUDT15 gene in Asian populations are closely related to adverse reactions such as leukopenia caused by mercaptopurine drug tolerance.This article reviews recent research advances in NUDT15 gene polymorphisms and mercaptopurine drug tolerance at home and abroad in recent years.