维生素D水平与重性抑郁症患者复发的相关性分析

The relationship between the level of vitamin D and the relapse of major depressive disorder

目的探讨血清维生素D水平与重性抑郁症患者复发机制的相关性。方法选取2018年5月—2019年5月湖南省脑科医院收治的重性抑郁症患者40例。其中,首发抑郁症患者20例(首发组),复发抑郁症患者20例(复发组)。同期招募20例健康志愿者作为对照组。检测3组血清25羟基维生素D[25(OH)D]水平。采用汉密尔顿抑郁量表(HAMD)对所有重性抑郁症患者的抑郁程度进行评分。分析首发和复发重性抑郁症患者血清维生素D水平与HAMD评分的相关性。结果复发组和首发组血清维生素D水平低于对照组(P<0.05),而复发组与首发组血清维生素D水平比较,差异无统计学意义(P>0.05)。首发和复发重性抑郁症患者血清维生素D水平与HAMD评分均呈负相关(r=-0.5869和-0.6847,P<0.05)。结论维生素D水平的缺乏可能是导致重性抑郁症患病与复发的一大诱因。有必要在临床治疗中对重性抑郁症患者的维生素D水平进行检测与补充。

Objective To investigate the correlation between serum vitamin D levels and recurrence in patients with major depression disorder.Methods Twenty patients with first episode of depression,twenty patients with relapse of depression and twenty healthy controls were enrolled in this study.The level of serum 25-hydroxy vitamin D[25(OH)D]was detected in each group.The degree of depression of all patients were assessed with Hamilton Depression Scale(HAMD).We also analyzed the correlation between the serum vitamin D level in patients with first-episode or recurrent MDD and HAMD scores.Results The serum vitamin D concentrations in patients with first-episode and recurrent MDD were significantly lower than those in the healthy controls,while there was no significant difference in serum vitamin D concentrations between patients with recurrent MDD and those with first-episode MDD.In addition,we found the negative correlation between the serum vitamin D levels and HAMD scores in first-episode and relapsed MDD patients.Conclusions Vitamin D deficiency may be a major cause of MDD and contribute to the recurrence.Therefore,it is necessary to detect and supplement vitamin D for MDD patients in clinical treatment.