双歧杆菌四联活菌治疗对肝硬化患者肝功能、细胞因子及肠道菌群的影响

Effect of Treatment with Viable Bifidobacterium Quadruple on Liver Function,Cytokines and Intestinal Flora in Patients with Liver Cirrhosis

目的探讨双歧杆菌四联活菌治疗对肝硬化患者肝功能、细胞因子及肠道菌群的影响。方法选取本院2015年1月—2019年12月收治200例肝硬化患者为研究对象,根据治疗方式的不同分为观察组和对照组,每组100例。对照组给予常规肝硬化治疗,观察组在对照组基础上给予双歧杆菌四联活菌片。比较2组用药前后肝功能、内毒素、细胞因子及肠道菌群的变化。结果2组治疗后丙氨酸转氨酶、天冬氨酸转氨酶、内毒素均显著低于治疗前,且观察组低于对照组(P<0.05)。2组治疗后肿瘤坏死因子-α、白介素-1、白介素-8水平较治疗前显著降低,且观察组低于对照组(P<0.05)。2组治疗后乳杆菌、双歧杆菌较治疗前升高,酵母样真菌较治疗前降低,且观察组变化幅度优于对照组(P<0.05)。2组治疗前后肠杆菌水平比较差异无统计学意义(P>0.05)。2组治疗后均未出现不良反应。结论双歧杆菌四联活菌片可在调节肠道菌群的同时,抑制炎性细胞,抵制内毒素侵入,避免肝功能损伤加重,对肝硬化的治疗具有良好辅助作用。

Objective To analyze the effect of treatment with viable Bifidobacterium quadruple on liver function,cytokines and intestinal flora in patients with liver cirrhosis.Methods From January 2015 to December 2019,200 cirrhotic patients treated in our hospital were selected as the research subjects.According to different treatment methods,they were divided into observation group and control group,with 100 cases in each group.The control group was treated with conventional cirrhosis,and the observation group was supplemented with Bifidobacterium quadruple viable tablets on the basis of the control group.The changes of liver function,endotoxin,cytokines and intestinal flora were compared before and after treatment.Results Alanine aminotransferase,aspartate transaminase and endotoxin in the two groups were significantly lower than those before treatment,and the indicators in the observation group were lower than those in the control group(P<0.05).After treatment,tumor necrosis factorα(TNF-α),interleukin(IL)-1 and IL-8 in the two groups were significantly lower than those before treatment,which were lower in the observation group than in the control group(P<0.05).After treatment,lactobacilli and bifidobacteria were increased and yeast-like fungi were decreased in the two groups,and the range of change of the observation group was better than that of the control group(P<0.05).There was no significant difference in the level of enterobacilli between the two groups before and after treatment(P>0.05),and there was no adverse reactions in the two groups after treatment.Conclusion The viable bifidobacterium quadruple tablets can regulate the intestinal flora while inhibiting inflammatory cells,resisting the invasion of endotoxin,avoiding aggravation of liver function damage,and has a good auxiliary effect in the treatment of patients with liver cirrhosis.