摘要
酶响应纳米药物是一类由内源性酶作用改变自身理化性质的纳米药物输送系统,能靶向输送药物,可控释亲脂性药物、蛋白质和基因等,改善其水溶性,降低毒副作用,延长循环时间;酶响应纳米药物可用于化学治疗、基因治疗、光热治疗以及光动力治疗等肿瘤治疗,由于其独特的刺激响应功能,在药物输送、疾病诊断及生物医学影像等方面有广泛的应用。该文综述了酶响应纳米药物最新研究进展,并对其面临的挑战和未来发展进行了展望。
Enzyme responsive nanomedicine is a kind of nano drug delivery system that changes its physical and chemical properties by endogenous enzyme.It can control the delivery and release of lipophilic drugs,proteins and genes,upgrade their water solubility,reduce their toxic and side effects,and increase their circulation time.Enzyme responsive nanomedicine can be applied in chemotherapy,gene therapy,photothermal therapy and photodynamic therapy for cancer treatment.This unique stimulus-response function is widely used in drug delivery,disease diagnosis and biomedical imaging.Herein,research progress of enzyme responsive nanomedicine is summarized,and the challenges and future development of enzyme responsive nanomedicine are discussed.
作者
安静
万江陵
杨祥良
李子福
AN Jing;WAN Jiangling;YANG Xiangliang;LI Zifu(College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan 430074,China;National Engineering Research Center for Nanomedicine,Wuhan 430074,China)
出处
《医药导报》
CAS
北大核心
2020年第9期1240-1251,共12页
Herald of Medicine
基金
国家自然科学基金资助项目(31972927,31700867)
华中科技大学学术前沿团队资助项目(2018QYTD01)。
关键词
纳米药物
酶响应
肿瘤治疗
Nanomedicine
Enzyme responsive
Tumor therapy
