超声造影时间-强度曲线诊断早期宫颈癌的临床价值

Value of time-intensity curve of contrast-enhanced ultrasound in early diagnosis of cervical cancer

目的探讨超声造影时间-强度曲线诊断早期宫颈癌的临床价值。方法选取我院经穿刺活检或手术病理证实的早期宫颈癌(T1和T2期)患者40例(早期宫颈癌组)、宫颈良性肿瘤患者65例(宫颈良性肿瘤组),两组均行经阴道超声和超声造影检查,定量分析时间-强度曲线参数包括达峰时间(TTP)、峰值强度(PI)、最大峰值强度比(PI/PIc)、曲线下面积(AUCTC)及平均渡越时间(MTT),比较两组各参数差异。结果早期宫颈癌组TTP明显缩短、PI明显增高、PI/PIc显著增大,与宫颈良性肿瘤组比较差异均有统计学意义(均P<0.05);而两组患者AUCTC和MTT比较差异均无统计学意义。结论超声造影时间-强度曲线可为早期宫颈癌诊断提供依据。

ObjectiveTo investigate the clinical value of time-intensity curve of contrast-enhanced ultrasound inearly diagnosis of cervical cancer.MethodsForty patients with early cervical cancer(T1 stage and T2 stage)confirmed bybiopsy or surgical pathology(cervical cancer group)and 65 patients with benign tumor(benign tumor group)were enrolled.Allpatients were examined by transvaginal ultrasound and contrast-enhanced ultrasound.The parameters of time-intensity curveincluding peak time of arrival(TTP),peak intensity of enhancement(PI),maximum peak intensity ratio(PI/PIc),area under thecurve(AUCTC)and mean transit time(MTT)were analyzed quantitatively.The differences between the two groups were compared.ResultsThe shorter TTP,stronger PI,and higher PI/PIc were significantly observed in cervical cancer group than those inbenign tumor group(all P<0.05). However,the AUCTCand MTT were not significantly different between the two groups.ConclusionThe time-intensity curve of contrast-enhanced ultrasound can provide the basis for the diagnosis of earlycervical cancer.