猪链球菌毒力因子研究进展

Progress on Virulence Factors of Streptococcus suis

猪链球菌作为条件致病菌,能引起人兽共患病,该病可在全球广泛流行,并导致严重疫情,研究发现该菌有很多毒力因子与细菌感染和致病密切相关。论文总结了猪链球菌的毒力因子H因子结合蛋白、荚膜唾液酸、猪链球菌富丝氨酸重复蛋白1、血红素结合蛋白SntA、菌毛蛋白、寡肽结合蛋白、烟酰胺单核苷酸转运蛋白PnuC、二肽基肽酶-4、5′-核苷酸酶、猪链球菌IgM降解酶、丝氨酸/苏氨酸激酶、VraSR调控系统、Spx蛋白、murB-potABCD操纵子、virD4-virB4分泌系统的研究进展,期待该菌毒力因子的研究能为疫苗和药物的开发提供思路。

Streptococcus suis,a conditional pathogen,is a zoonotic agent and becomes widely popular all over the world,resulting in serious outbreaks.Therefore,more and more concerns are focused on it.It has been found that Streptococcus suis has many virulence factors,all of which are closely related to bacterial infection and pathogenesis.This paper mainly summarized the progress on virulence factors of Streptococcus suis that are factor H-binding protein,capsular sialic acid,Streptococcus suis serine-rich repeat protein 1,heme-binding protein SntA,pilin protein,oligopeptide-binding protein,nicotinamide mononucleotide transporter PnuC,dipeptidyl peptidase IV,5′-nucleotidase,the IgM degrading enzyme of Streptococcus suis,serine/threonine protein kinase,VraSR two-component system,Spx protein,murB-potABCD operon,virD4-virB4 secretion system.It is expected that the research of virulence factors can provide ideas for developing vaccines and drugs.