摘要
代谢组学借鉴基因组学和蛋白质组学的科学思路,对机体内所有内源性小分子进行定量或定性分析,并探索内源性代谢物与机体生理病理变化的相互关系。分析对象多以分子质量1 ku以下的小分子。近年以来,代谢组学作为鉴定新的毒性生物标志物工具的巨大潜力已经被证实。通过非侵入性代谢组学分析鉴定哺乳动物中的生物标志物是特别有价值的工作。论文从代谢组学的研究平台、数据统计分析及其在毒性生物标志物的应用现状进行了综述。
Metabonomics uses the scientific ideas of genomics and proteomics for reference to make quantitative or qualitative analysis of all endogenous small molecules in the body,and to explore the relationship between endogenous metabolites and physiological and pathological changes of the body.Its analytical objects are mostly small molecules with relative molecular weight less than 1000.In recent years,metabonomics has been proved to have great potentiality as a tool to identify new toxic biomarkers.Identification of biomarkers in mammals by noninvasive metabonomics will be of particular value.In this paper,we reviewed the research platform of metabonomics,statistical analysis of data and the current application of metabonomics in toxic biomarkers.
作者
程鸿静
谢书宇
陈冬梅
CHENG Hong-jing;XIE Shu-yu;CHEN Dong-mei(National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for Detection of Veterinary Drug Residues,Wuhan,Hubei,430070,China)
出处
《动物医学进展》
北大核心
2020年第9期92-97,共6页
Progress In Veterinary Medicine
基金
国家重点研发计划项目(2017YFD0501402)
国家自然科学基金项目(31572570)
2019年畜禽产品质量安全风险评估项目(GJFP2019007)。
