纤维肌痛症发病机制的研究进展

Research progress the pathogenesis of fibromyalgia

纤维肌痛症(fibromyalgia,FM)是一种骨骼肌肉广泛持续性疼痛为主要特征的慢性进展性疾病,临床上往往伴随焦虑、抑郁、睡眠障碍、慢性疲乏或胃肠道功能紊乱等症状。其发病机制仍不明,目前尚无确切疗法,严重影响患者生活质量。近年来研究发现FM与氧化应激、中枢疼痛敏化、转运体蛋白遗传多态性、生物胺含量及功能异常、炎症因子过度释放、肠道菌群紊乱或维生素D缺乏等相关。本文就FM发病机制进行综述,为进一步研究提供参考。

Fibromyalgia(FM)is a syndrome characterized by widely and persistent pain in skeletal muscles,often accompanied by symptoms of anxiety,depression,sleep disturbance,chronic fatigue or gastrointestinal disorder symptoms.Its pathogenesis is still unknown and there is no effective treatment so far,which seriously affects the quality of life of patients.Recent studies have found that fibromyalgia is associated with oxidative stress,central pain sensitization,translocator protein polymorphism,abnormal biogenic amine output and function,excessive release of inflammatory factors,gut microbiota disorders or vitamin D deficiency.This review summarized the pathogenesis of fibromyalgia to provides some clues for further research.