摘要
骨折的愈合一直是骨科医师关注的重点问题之一,目前仍有10%的骨折患者存在骨折愈合不良或骨不连等情况。近年来,有研究显示神经生长因子(NGF)具有促进骨折愈合的作用,本文就NGF促进骨折愈合的机制和研究进展做一综述。NGF能促进骨折断端的血管再生和神经纤维长入,对骨细胞的增殖和分化也有重要作用,新的基础实验和临床试验证实NGF对骨折愈合的促进作用,并进一步揭示了其可能的作用机制。骨折愈合过程是复杂的,NGF促进骨折愈合可能是通过多种机制,不应仅局限于单方面的机制研究。对NGF的进一步研究可以为促进骨折愈合尤其是治疗骨不连提供新思路。
Fracture healing has long been a major concern for orthopedists.Currently,about 10%of fracture patients still have poor fracture healing or bone nonunion.In recent years,research has found that nerve growth factor(NGF)can promote fracture healing.This article reviews the mechanism and research progress of NGF in promoting fracture healing.NGF can promote vascular regeneration and nerve growth at callus and plays an important role in the proliferation and migration of bone cells.New animal experiments and clinical trials have confirmed the role of NGF in promoting fracture healing and further revealed its possible mechanism of action.Further research on NGF can provide new ideas for promoting fracture healing,especially for treating nonunion.
作者
杨冰
马天宇
马维
YANG Bing;MA Tianyu;MA Wei(Department of Orthopedics,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2020年第4期546-551,共6页
Acta Academiae Medicinae Sinicae
基金
河北省财政厅课题(3101-04-04-02-07-23)。
关键词
神经生长因子
骨折愈合
血管内皮生长因子
酪氨酸激酶受体A
nerve growth factor
fracture healing
vascular endothelial growth factor
tyrosine kinase receptor A
