柴胡加龙骨牡蛎汤联合颤三针治疗帕金森病临床研究

Clinical Study on Chaihu Jia Longgu Muli Tang Combined with Three Needles for Tremor in Treating Parkinson Disease

目的:观察柴胡加龙骨牡蛎汤联合颤三针治疗帕金森病(PD)的临床疗效。方法:选取68例PD患者,按随机数字表法分为试验组、参照组各34例。参照组予左旋多巴片治疗,试验组予柴胡加龙骨牡蛎汤联合颤三针治疗,2组均治疗2个月。检测2组血清神经胶质纤维酸性蛋白(GFAP)、丙二醛(MDA)、超氧化物歧化酶(SOD)水平,比较2组中医证候积分、认知功能、运动功能及临床疗效。结果:治疗后,2组中医证候积分均较治疗前降低,且试验组较参照组低(P<0.05)。试验组总有效率为94.12%,高于参照组的73.53%(P<0.05)。治疗后,2组血清GFAP、MDA水平均较治疗前降低(P<0.05),血清SOD水平均较治疗前升高(P<0.05);试验组血清GFAP、MDA水平均低于参照组(P<0.05),血清SOD水平高于参照组(P<0.05)。治疗后,2组简易智力状态量表(MMSE)评分均较治疗前升高(P<0.05),且试验组MMSE评分高于参照组(P<0.05);2组老年痴呆量表-认知(ADAS-cog)、帕金森综合评分量表(UPDRS-Ⅲ)、社会功能活动问卷(FAQ)评分均较治疗前降低(P<0.05),且试验组ADAS-cog、UPDRS-Ⅲ、FAQ评分均低于参照组(P<0.05)。结论:柴胡加龙骨牡蛎汤联合颤三针治疗PD能有效调节血清GFAP、SOD、MDA水平,改善患者的临床症状,有助于恢复其认知及运动功能。

Objective: To observe the clinical effect of Chaihu Jia Longgu Muli tang combined with three needles for tremor in treating Parkinson disease(PD). Methods: A total of 68 cases of PD patients were selected and divided into the experiment group and the reference group according to the random number table method, 34 cases in each group. The reference group was given levodopa tablets,and the experiment group was given Chaihu Jia Longgu Muli tang combined with three needles for tremor. Both groups were treated for two months. The levels of glial fibrillary acidic protein(GFAP),malondialdehyde(MDA) and superoxide dismutase(SOD) in serum in the two groups were detected. The Chinese medicine syndrome scores,cognitive function,motor function and clinical effect were compared between the two groups. Results:After treatment, the Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,and the scores in the experiment group were lower than those in the reference group(P<0.05). The total effective rate was 94.12% in the experiment group, higher than that of 73.53% in the reference group(P<0.05). After treatment,in the two groups,the levels of GFAP and MDA in serum were decreased when compared with those before treatment(P<0.05),and the levels of SOD in serum were increased when compared with those before treatment(P<0.05);in the experiment group,the levels of GFAP and MDA in serum were lower than those in the reference group(P<0.05),and the level of SOD in serum was higher than that in the reference group(P<0.05). After treatment,the scores of Mini-Mental State Examination(MMSE) in the two groups were increased when compared with those before treatment(P<0.05),and the score in the experiment group was higher than that in the reference group(P<0.05);the scores of Alzheimer’s Disease Assessment Scale-Cognitive section(ADAS-cog), Unified Parkinson Disease Rating Scale(UPDRS-Ⅲ) and Functional Activities Questionnaire(FAQ) in the two groups were decreased when compared with those before treatment(P<0.05),and the three scores in the experiment group were lower than those in the reference group(P<0.05). Conclusion:The therapy of Chaihu Jia Longgu Muli tang combined with three needles for tremor can effectively regulate the levels of GFAP,SOD and MDA in serum,improve the clinical symptoms,and conduce to recovering cognitive and motor function.