小儿暴发性心肌炎氨基末端脑利钠肽前体测定的临床意义

Clinical significance of the determination of N-terminal pro brain natriuretic peptide in children with fulminant myocarditis

目的探讨小儿暴发性心肌炎氨基末端脑利钠肽前体(NT-proBNP)测定的临床意义,以指导临床小儿暴发性心肌炎的诊断和治疗。方法选择我院于2008~2018年10年间小儿心脏科确诊的14例暴发性心肌炎患儿,同期选择轻型心肌炎患儿14例和健康体检儿童14例作为对照组。采用化学发光法检测NT-proBNP数值。结果暴发性心肌炎患儿急性期NT-proBNP与暴发性心肌炎恢复期、轻型心肌炎组、对照组比较明显升高,差异有统计学意义(P<0.05)。轻型心肌炎组NT-proBNP与对照组比较也明显升高,差异有统计学意义(P<0.05),结论NT-proBNP可以作为暴发性心肌炎诊断和判断预后的重要的指标。

Objective To investigate clinical value of N-terminal pro brain natriuretic peptide(NT-proBNP)detection in children with fulminant myocarditis(FM),in order to guide the diagnosis and treatment of children with FM.Methods A total of 14 children with FM and 14 children with mild myocarditis treated in our hospital from 2008 to 2018 were selected.Fourteen healthy children were selected as healthy control group.The level of NT-proBNP was tested by automatic biochemical analyzer.Results The level of NT-proBNP in FM children at acute stage was significantly higher than that in FM children at recovery stage,the children with mild mycarditis and healthy control group(P<0.05).The level of NT-proBNP in mild myocarditis was significantly higher than that in healthy control group(P<0.05).Conclusion The level of NT-proBNP may be used as an important marker in the diagnosis and the judgement of prognosis of fulminant myocarditis.