翼状胬肉切除联合自体角膜缘干细胞移植术对翼状胬肉患者视觉质量和泪膜功能的影响

Effect of Pterygium Excision Combined with Autologous Limbal Stem Cell Transplantation on Visual Quality and Tear Film Function of Pterygium

目的:探讨翼状胬肉切除联合自体角膜缘干细胞移植术治疗翼状胬肉的疗效及对视觉质量和泪膜功能的影响。方法:选取2017年2月~2018年12月期间我院收治的翼状胬肉患者201例,根据乱数表法将患者随机分为对照组(n=100)和研究组(n=101),对照组给予翼状胬肉切除术治疗,研究组在此基础上联合自体角膜缘干细胞移植术治疗。比较两组临床疗效、视觉质量、泪膜功能、并发症以及角膜上皮修复时间。结果:研究组术后6个月的临床总有效率为90.10%(91/101),显著高于对照组的73.00%(73/100)(P<0.05)。研究组角膜上皮修复时间均短于对照组(P<0.05)。两组术后6个月角膜散光度降低,且研究组低于对照组(P<0.05);角膜水平曲度、角膜垂直曲度、视力、泪膜破裂时间(BUT)、基础泪液分泌试验(SIT)均升高,且研究组高于对照组(P<0.05)。研究组随访期间并发症发生率低于对照组(P<0.05)。结论:翼状胬肉患者在翼状胬肉切除术的基础上联合自体角膜缘干细胞移植术治疗,疗效确切,可有效改善患者的视觉质量和泪膜功能,并可减少术后并发症的发生率,临床应用价值较高。

Objective:To investigate the effect of pterygium excision combined with autologous limbal stem cell transplantation on visual quality and tear film function of patients with pterygium.Methods:201 patients with pterygium received by our hospital from February 2017 to December 2018 were selected,they were randomly divided into control group(n=100)and study group(n=101)according to random number table method.The control group was treated with pterygium excision,while the study group was treated with pterygium excision combined with autologous limbal stem cell transplantation.The clinical efficacy,visual quality,tear film function,complications and corneal epithelial repair time were compared between the two groups.Results:The total effective rate of the study group was 90.10%(91/101)at 6 months after operation,which was significantly higher than 73.00%(73/100)of the control group(P<0.05).The corneal epithelial repair time in the study group was shorter than that in the control group(P<0.05).The corneal astigmatism of the two groups decreased 6 months after operation,and the corneal horizontal curvature,corneal vertical curvature,visual acuity,tear film rupture time(BUT),basic tear secretion test(SIT)of the study group were higher than those of the control group(P<0.05).The incidence of complications in the study group was lower than that in the control group during the follow-up period(P<0.05).Conclusion:Pterygium excision combined with autologous limbal stem cell transplantation is effective in the treatment of pterygium.It can effectively improve visual quality and tear film function,and reduce the occurrence of postoperative complications.It has high clinical value.