急性脑梗死患者血清RBP、NLR、PTX3水平与颈动脉粥样硬化斑块稳定性的关系研究

Relationship between the Levels of RBP,NLR,PTX3 and the Stability of Carotid Atherosclerotic Plaque in Patients with Acute Cerebral Infarction

目的:探讨急性脑梗死(ACI)患者血清视黄醇结合蛋白(RBP)、中性粒细胞与淋巴细胞比值(NLR)、内正五聚蛋白3(PTX3)水平与颈动脉粥样硬化斑块稳定性的关系。方法:收集我院2017年1月~2019年1月收治的300例ACI患者,根据颈动脉粥样硬化斑块超声结果分为稳定斑块组(n=173)和不稳定斑块组(n=127),另选同期在我院体检中心进行健康体检的志愿者100例为对照组。对ACI患者和对照组进行RBP、NLR、PTX3、血脂指标的检测,并进行组间统计学对比。采用Pearson检验对ACI患者的RBP、NLR、PTX3与血脂指标的相关性进行分析。结果:三组受试者性别、年龄、体质指数(BMI)、吸烟史、饮酒史等基础资料对比无显著性差异(P>0.05)。稳定斑块组、不稳定斑块组患者的RBP、NLR、PTX3水平均高于对照组,且不稳定斑块组上述指标水平高于稳定斑块组(P<0.05)。稳定斑块组、不稳定斑块组患者的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、纤维蛋白原(FIB)水平均高于对照组,且不稳定斑块组上述指标水平高于稳定斑块组(P<0.05)。经Pearson检验分析,ACI患者的RBP、NLR、PTX3水平与TC、TG、LDL-C、FIB均呈正相关性(P<0.05)。结论:在ACI患者中RBP、NLR、PTX3水平较高,并与患者的颈动脉粥样硬化斑块的稳定性有紧密的关联性。初步推测RBP、NLR、PTX3可能参与颈动脉粥样硬化斑块的形成,进而影响ACI疾病的发生发展过程。

Objective:To investigate the relationship between the level of serum retinol binding protein(RBP),the ratio of neutrophils to lymphocytes(NLR),the endopentamerin 3(PTX3)and the stability of carotid atherosclerotic plaque in patients with acute cerebral infarction(ACI).Methods:300 patients with ACI who were admitted to our hospital from January 2017 to January 2019 were enrolled in this study.According to the results of carotid atherosclerotic plaque ultrasound,they were divided into stable plaque group(n=173)and unstable plaque group(n=127).Another 100 volunteers who had physical examination in the physical examination center of our hospital at the same time were selected as the control group.The RBP,NLR,PTX3 and blood lipid indexes of patients with ACI and control group were detected,and the statistical comparison between groups was made.Pearson test was used to analyze the correlation between RBP,NLR,PTX3 and blood lipid indexes in patients with ACI.Results:There was no significant difference in gender,age,body mass index(BMI),smoking history and drinking history among the three groups(P>0.05).The levels of RBP,NLR and PTX3 in stable plaque group and unstable plaque group were higher than those in control group,and the levels of the above indexes in unstable plaque group were higher than those in stable plaque group(P<0.05).The levels of total cholesterol(TC),triglyceride(TG),low-density lipoprotein(LDL-C)and fibrinogen(FIB)in stable plaque group and unstable plaque group were higher than those in the control group.The levels of the above indexes in the unstable plaque group were higher than those in the stable plaque group(P<0.05).According to Pearson test,the levels of RBP,NLR and PTX3 in patients with ACI were positively correlated with TC,TG,LDL-C and FIB(P<0.05).Conclusion:The levels of RBP,NLR and PTX3 are higher in patients with ACI,and they are closely related to the stability of carotid atherosclerotic plaque.It is preliminarily speculated that RBP,NLR and PTX3 may be involved in the formation of carotid atherosclerotic plaque,and then affect the occurrence and development of ACI disease.