鉴别细菌与病毒感染的宿主生物标志物研究进展

Research Progress of Host Biomarkers for Identification of Bacterial and Viral Infections

感染是临床常见病症,具有高发病率和病死率。早期识别及准确评估细菌感染和病毒感染是目前临床医师公认的难题。宿主生物标志物源自机体对感染的反应,近年来其作为感染类型鉴别相关标志物成为国内外研究的热点。其中,降钙素原、C反应蛋白(CRP)、人中性粒细胞载脂蛋白、白细胞介素-6、黏病毒抗性蛋白A以及新型宿主蛋白联合标志物(肿瘤坏死因子相关凋亡诱导配体+干扰素诱导蛋白-10+CRP)等一系列宿主生物标志物被报道参与了感染的发病与炎症调控机制,在感染类型的鉴别诊断中发挥重要作用。未来,宿主生物标志物的有效联用可能成为鉴别细菌与病毒感染的实验室诊断标准。

Infection is a common clinical condition with high morbidity and mortality.Early identification and accurate assessment of bacterial and viral infections are currently recognized challenges by the clinicians.The host biomarker is derived from the body’ s response to infection,which has become a research hotspot at home and abroad as a marker for identifying the type of infection.Among them,a series of host biomarkers,such as procalcitonin,C-reactive protein( CRP),human neutrophil apolipoprotein,interleukin-6,Myxovirus resistance protein A,and novel host protein combined markers( tumor necrosis factor-related apoptosis-inducing ligand + interferon-inducing protein-10 + CRP) have been reported to be involved in the pathogenesis of infection and inflammation regulation mechanisms,and play important roles in the differential diagnosis of infection types.In the future,the effective combination of host biomarkers may become a laboratory diagnostic standard for the identification of bacterial and viral infections.