过敏性哮喘中Th2免疫反应的作用和相关机制

Role and Mechanisms of Th2 Immune Response in Allergic Asthma

哮喘是多种细胞及细胞组分参与的慢性气道炎症,常伴有广泛而多变的气流阻塞,一般可自行或通过治疗逆转。过敏性哮喘主要是由辅助性T细胞2(Th2)介导的免疫反应。当变应原进入机体后,免疫细胞被激活,导致多种细胞因子募集和释放。由细胞因子导致的免疫功能紊乱受到了越来越多的关注,细胞因子基因剔除或过表达,对疾病的发生和发展产生不同的影响。明确Th2免疫反应机制在过敏性哮喘中的作用,可为过敏性哮喘的诊断和针对Th2细胞信号转导开发治疗过敏性哮喘的新药提供相应的理论基础。

Asthma is a chronic airway inflammation in which a variety of cells and cell components are inolved.These symptoms are often accompanied by extensive and variable airflow obstruction,which can usually be reversed by itself or through treatment.Allergic asthma is an immune response mainly mediated by helper T2( Th2) cells.When allergens enter the body,immune cells are activated,leading to the recruitment and release of a variety of cytokines.More and more attention is paid to immune dysfunction caused by these cytokines.Gene deletion or overexpression of these cytokines will have different effects on the development of the diseases.Clarifying the role of Th2 immune response mechanism in allergic asthma will provide theoretical basis for the diagnosis and the development of new drugs for the treatment of allergic asthma.