粪菌移植治疗克罗恩病的相关研究进展

Related Research Advances in Treatment of Crohn’s Disease by Fecal Microbiota Transplantation

粪菌移植(FMT)是治疗肠道菌群失调的新兴治疗方法,已成功应用于艰难梭菌感染的治疗,受到国际医学界的广泛关注。克罗恩病(CD)是一种慢性复发性自身免疫学疾病,目前认为是易感基因、环境、肠道菌群等因素综合引起机体异常免疫应答所致,病程迁延不愈,致残、致死率高,患者生活质量下降,经济负担加重,传统治疗效果不佳。肠道菌群和机体共存亡、共发育、共进化、共代谢、互调控,在CD的发生、发展中发挥关键作用。FMT作为一种以重建肠道菌群平衡为核心的治疗策略或将成为治疗CD的重要突破点。

Fecal microbiota transplantation(FMT)is an emerging treatment method for intestinal flora disorders,which has been successfully applied to the treatment of clostridium difficile infection,and has received extensive international attention.Crohn’s disease(CD)is a chronic recurrent autoimmune disease,which is caused by the abnormal immune response due to the combination of susceptibility genes,environment,intestinal flora and other factors CD is featured with a prolonged course,high disability and mortality,reduced quality of life,increased economic burden,and poor therapeutic effect of traditional treatment.The intestinal microbiota survives,develops,evolves,metabolizes together and regulates each other with the body,which plays a key role in the occurrence and development of CD.FMT may become an important breakthrough point in the treatment of CD which is attributed to reestablishing the balance of intestinal flora.