哮喘-慢性阻塞性肺疾病重叠综合征的研究概况

General Research Situation of Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome

哮喘-慢性阻塞性肺疾病重叠综合征(ACOS)是中后期慢性阻塞性肺疾病(COPD)患者死亡的主要原因,兼具哮喘和COPD的特点。哮喘的主要病理特点是以气道平滑肌增生及肥大为主的气道重构,COPD的主要病理特点是以中性粒细胞性炎症为主的慢性气道炎症。两者的发病机制可互相影响及互相转化。ACOS突出的病理表现亦是气道重构和炎症,但发病机制不明,治疗受限。如能明确哮喘、COPD和ACOS发生的关系及关键作用靶点,将能为实现精准治疗提供依据。

Asthma-chronic obstructive pulmonary disease overlap syndrome( ACOS) is the main cause of death in COPD patients,which has the characteristics of both asthma and COPD.The main pathological feature of asthma is airway remodeling due to airway smooth muscle hyperplasia and hypertrophy,while the main pathological feature of COPD is chronic inflammation due to neutrophilic inflammation.The pathogenesis of the two can influence each other and mutually transform.The main clinical and pathological features of ACOS are chronic inflammation and airway remodeling,however the mechanisms are unclear,and the treatment is limited.We hope to discover the relationship between asthma,COPD and ACOS,and identify the potential key drug targets and provide novel strategies for precise clinical treatment.