胃肠道间质瘤144例临床和病理特征的研究

To explore the clinicopathological features of gastrointestinal stromal tumors in 144 cases

目的:分析胃肠道间质瘤(GIST)患者临床病理特征,总结胃肠道间质瘤病理诊断及鉴别诊断要点。方法:收集胃肠道间质瘤患者144例临床病理资料,统计肿瘤组织学类型及免疫组织化学表达,分析肿瘤的大小、核分裂象数及生长部位等因素与肿瘤危险度的关系,采用SPSS17.0统计学软件对数据进行统计学分析。结果:144例患者中男57例,女87例,年龄36~71岁;肿瘤发生于胃部100例(69.44%),非胃部44例(30.56%);肿瘤危险度特征为极低危险度26例(18.06%),低危险度54例(37.50%),中等危险度30例(20.83%),高危险度34例(23.61%)。结论:胃肠道间质瘤好发于胃部,组织学易与其他梭形细胞肿瘤相混淆,CD117,DOG-1及CD34为肿瘤诊断的免疫组织化学标记,肿瘤具有独立的危险度影响因子。

Objective:To investigate the clinicopathological features of gastrointestinal stromal tumors(GIST)and summarize the key points of diagnosis and differential diagnosis of gastrointestinal stromal tumors.Methods:Collected in our hospital treated 144 cases of gastrointestinal stromal tumor patients clinical data,statistical tumor histology and immunohistochemical expression,analysis the size of the tumor,and nuclear fission like number,growing relationship between tumor and the influence factors,such as risk areas,using SPSS17.0 statistical software for statistical data analysis.Results:All 144 patients,male 57 cases,87 cases of female,age 36 years old to 71 years old,tumor occurred in 100 cases(69.44%)of the stomach,the stomach 44 cases(30.56%),tumor risk characteristics of very low risk of 26 cases(18.06%),low risk of 54 cases(37.50%),30 cases(20.83%),medium risk high risk 34 cases(23.61%).Conclusion:Gastrointestinal stromal tumors are common in the stomach,histological easily confused with other spindle cell tumor,CD117,DOG-1 and CD34 immunohistochemical markers for tumor diagnosis and tumor with independent risk factors.