局灶性皮质发育不良的表观遗传学研究进展

Research progress in epigenetic studies of focal cortical dysplasia

局灶性皮质发育不良(FCD)属于皮质发育畸形的范畴,是胚胎发育早期神经元异常增殖或异常移行所导致的一种疾病。表观遗传学是指在基因的核苷酸序列不发生改变的情况下,基因表达发生改变,而这些改变是可遗传的。它主要通过DNA的甲基化、组蛋白修饰、染色质重塑和非编码RNA这4种方式来调控基因的表达。目前认为,表观遗传学机制在FCD的发病过程中可能扮演着重要的角色,已成为FCD研究的热点。文中将对FCD的表观遗传学研究进展做一综述。

Belonging to the mlformations of cortical development category,focal cortical dysplasia(FCD)is a kind of desease caused by abnormal proliferation or abnormal migration of neurons in early embryo development.Epigenetics refers to changes in gene expression without changes in the nucleotide sequence of a gene,and these changes are heritable.It regulates gene expression mainly through DNA methylation,histone modification,chromatin remodeling and non-coding RNA.It is now considered that the epigenetic mechanism may be closely related to the pathogenesis of FCD,which has become a hotspot of FCD research.This paper will review the advances in epigenetic studies of FCD.