不同致泻性大肠杆菌感染调控细胞信号通路的研究进展

Research progress on signal pathways of different diarrhea-causing Escherichia coli infections

腹泻性大肠杆菌是在全世界引起人类和动物疾病的主要病原之一,也给社会经济带来巨大损失。根据致病机理的不同,可将腹泻性大肠杆菌分为6种:肠致病性大肠杆菌、肠出血性大肠杆菌、肠凝集性大肠杆菌、产肠毒素大肠杆菌、扩散黏附性大肠杆菌和肠侵袭性大肠杆菌。不同致病型大肠杆菌侵入宿主的方式及引起的炎症反应有所不同。文章综合分析了致病机制不同的大肠杆菌在调控宿主细胞信号通路方式上的不同,从炎症级联反应方面阐述了不同致病类型大肠杆菌的感染特征,并探讨了炎症信号通路与病原感染、预防和治疗的关系,以期为腹泻性大肠杆菌致病机制及治疗方案的研究提供帮助。

Diarrhea Escherichia coli is one of the main pathogens causing human and animal diseases in the world,and brings great losses to the social economy.According to different pathogenic mechanisms,diarrhea Escherichia coli can be divided into six types:enteropathogenic E.coli,enterohemorrhagic E.coli,enteragglutinative E.coli,enterotoxigenic E.coli,diffusion adhesive E.coli and enteroinvasive E.coli.Different pathogenic E.coli invades the host in different ways and causes different inflammatory reactions.In this paper,the differences of inflammatory signal pathways caused by different pathogenic E.coli were analyzed,and the relationship between inflammatory signal pathways and pathogenic infection,prevention and treatment were discussed.The paper aims to lay a foundation for the study of pathogenic mechanism and treatment of diarrhea E.coli.