干扰素α-2b抑制瘢痕形成的研究与热点

Review of interferon alpha-2b inhibiting scar formation

背景:干扰素是一种类似多肽激素的细胞功能调节物质,生物活性广泛,具有抗病毒、抗增殖活性、抗肿瘤、免疫调节等功能。目的:综述干扰素α-2b药物在多个器官抑制瘢痕形成的作用,以期为临床治疗瘢痕形成提供理论依据。方法:以“干扰素α-2b,成纤维细胞,瘢痕,增生性瘢痕,瘢痕疙瘩”和“IFNα-2b,Interferonα-2b,fibroblasts,scar,hypertrophic scar,keloid”为检索词,从万方、维普、CNKI、PubMed、Web of Science、Elsevier Science Direct等数据库中进行检索筛选,检索时间为1950至2020年。最终纳入42篇文献进行综述。结果与结论:①干扰素α-2b能够抑制瘢痕的发生与发展,可减少细胞外基质胶原蛋白生成,抑制成纤维细胞增殖,也可作用于纤维化相关的细胞因子和基因靶点;②上述研究可为临床上应用干扰素α-2b治疗瘢痕形成提供理论依据。

BACKGROUND:Interferon is a kind of cellular regulatory substance similar to polypeptide hormone,which has a wide range of biological activities,such as antivirus,anti-proliferation,antitumor and immunomodulatory functions.OBJECTIVE:To review the effect of interferonα-2b to inhibit scar formation in multiple organs,so as to provide a theoretical basis for clinical treatment of scar and fibrosis diseases.METHODS:A computer-based online search of WanFang,VIP,CNKI,PubMed,Web of Science and Elsevier Science Direct databases was performed to retrieve papers published during 1950-2020 with the search terms of“IFNα-2b,interferonα-2b,fibroblasts,scar,hypertrophic scar,keloid”in Chinese and English,respectively.A total of 42 papers were included for the final analysis.RESULTS AND CONCLUSION:Interferonα-2b can inhibit the occurrence and development of scar,reduce the production of extracellular matrix collagen,inhibit the proliferation of fibroblasts,and act on cytokines and gene targets related to fibrosis.Findings from this study provide a theoretical basis for the clinical application of interferonα-2b in the treatment of scar formation.