先天性脊柱侧弯遗传及环境病因学研究进展

Progress in genetic and environmental etiology of congenital scoliosis

先天性脊柱侧弯(congenital scoliosis, CS)是由于胚胎期椎体的形成障碍或分节不良所引起的一种以纵向和旋转不平衡为特征的畸形,前者所致的半椎体畸形是导致先天性脊柱侧弯的主要原因。引起CS的病因极其复杂,目前尚不清楚,近年来,关于CS的病因相关研究较多,大多研究认为遗传与环境是CS重要致病因素。本文就CS发病原因中的遗传因素与环境因素的研究进展作一综述,以期为该病的诊疗提供新思路。

Congenital scoliosis(CS)is a deformity characterized by longitudinal and rotational imbalance caused by formation disorder and malsegmentation of embryonic vertebral bodies.Hemivertebra deformity caused by the former is the main type of congenital scoliosis.The etiology of CS is relatively complex and unclear.In recent years,there have been many researches on the etiology of CS,most of which agree that heredity and environment are the main pathogenesis factors.Advances in genetic and environmental factors related to the pathogenesis of CS are reviewed in this article.