拉贝洛尔、硝苯地平联合硫酸镁治疗妊娠期高血压子痫前期的效果比较

Comparation of the effect of labetalol,nifedipine combined with magnesium sulfate in the treatment of pregnancy induced hypertension and preeclampsia

目的研究妊娠期高血压子痫前期患者采用拉贝洛尔+硫酸镁治疗的临床效果。方法选取2018年1月至2019年12月我院接收的124例子痫前期患者,将其随机分为对照组和观察组,各62例。对照组给予硫酸镁+硝苯地平治疗,观察组给予拉贝洛尔+硫酸镁治疗。比较两组治疗效果。结果治疗后,两组舒张压、收缩压、24 h尿蛋白、BNP水平、血黏度、血细胞压积均降低,且观察组低于对照组(P<0.05)。观察组不良妊娠结局总发生率低于对照组(P<0.05)。观察组治疗总有效率高于对照组(P<0.05)。结论硫酸镁+拉贝洛尔治疗子痫前期能稳定病情,改善妊娠结局,值得推广。

Objective To study the clinical effect of labetalol+magnesium sulfate in the treatment of pregnancy induced hypertension and preeclampsia.Methods A total of 124 patients with preeclampsia received in our hospital from January 2018 to December 2019 were randomly divided into control group and observation group,with 62 cases in each group.The control group was treated with magnesium sulfate+nifedipine,and the observation group was treated with labetalol+magnesium sulfate.The therapeutic effects of the two groups were compared.Results After treatment,diastolic blood pressure,systolic blood pressure,24 h urinary protein,BNP levels,blood viscosity and hematocrit in the two groups decreased,and those in the observation group were lower than the control group(P<0.05).The total incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group(P<0.05).The total effective rate of treatment in the observation group was higher than that of the control group(P<0.05).Conclusion Magnesium sulfate+labetalol in the treatment of preeclampsia can stabilize the condition and improve the pregnancy outcome,which is worthy of promotion.