降钙素原检测对婴幼儿细菌性肺炎病情判断及预后的影响

Effect of procalcitonin detection on the condition judgment and prognosis of infantile bacterial pneumonia

目的探讨降钙素原检测对婴幼儿细菌性肺炎病情判断及预后的影响。方法2018年1月至2019年12月,选择我院200例肺炎患儿作为观察组,另选取200例健康婴幼儿作为对照组,检测和分析其血清降钙素原、痰液降钙素原、血清C反应蛋白水平;比较不同降钙素原水平细菌性肺炎患儿的抗生素使用时间及住院时间。结果观察组的血清降钙素原、痰液降钙素原、血清C反应蛋白水平均高于对照组(P<0.05)。细菌性肺炎组的血清降钙素原、痰液降钙素原水平高于病毒性肺炎组及肺炎支原体肺炎组(P<0.05)。重症组的血清降钙素原、痰液降钙素原水平均高于轻症组(P<0.05)。血清降钙素原、痰液降钙素原<0.5 ng/mL组的抗生素使用时间、住院时间短于血清降钙素原、痰液降钙素原≥0.5 ng/mL组(P<0.05)。结论血清及痰液降钙素原检测可灵敏反映婴幼儿细菌性肺炎的发生、病情严重程度及预后。

Objective To explore the effect of procalcitonin detection on the condition judgment and prognosis of infantile bacterial pneumonia.Methods From January 2018 to December 2019,200 cases of pneumonia children in our hospital were selected as observation group,and 200 healthy infants were selected as control group.The serum procalcitonin,sputum procalcitonin and serum C-reactive protein levels were detected and analyzed;the antibiotic use time and hospitalization time of children with bacterial pneumonia with different procalcitonin levels were compared.Results The levels of serum procalcitonin,sputum procalcitonin and serum C-reactive protein in the observation group were higher than those in the control group(P<0.05).The levels of serum procalcitonin and sputum procalcitonin in the bacterial pneumonia group were higher than those in the viral pneumonia group and Mycoplasma pneumoniae pneumonia group(P<0.05).The levels of serum procalcitonin and sputum procalcitonin in the severe group were higher than those in the mild group(P<0.05).The antibiotic use time and hospitalization time in the serum procalcitonin and sputum procalcitonin<0.5 ng/mL groups were shorter than those in the serum procalcitonin and sputum procalcitonin≥0.5 ng/mL groups(P<0.05).Conclusion The detection of serum and sputum procalcitonin can sensitively reflect the occurrence,severity and prognosis of infantile bacterial pneumonia.