液体活检在淋巴瘤中的应用进展

Progress of liquid biopsy in lymphoma

"液体活检"是通过血液样本检测肿瘤DNA的一种无创手段。肿瘤DNA在血液中以细胞形式即循环肿瘤细胞(circulating tumor cells,CTCs)或者游离形式即血清游离DNA (cell-free DNA,cfDNA)被检测到。cfDNA是细胞坏死或者凋亡之后进入血液的长度较短(<200个碱基对)的双链DNA,肿瘤组织和非肿瘤组织都可以产生cfDNA,其中肿瘤组织来源的DNA即循环肿瘤DNA(circulating-tumor DNA,ctDNA)[1-2]。

Liquid biopsy is used to detect cell-free DNA in healthy subjects and in lymphoma patients with the development of next-generation sequencing.So far,the effect of liquid biopsy in disease prognosis,longitudinal monitoring of treatment response and surveillance of long-term remission or relapse in diffuse large B cell lymphoma has been reported in several articles.In addition,those effects in other types of lymphoma are also being assessed.In this review,we will summarize the application of liquid biopsy in different types of lymphomas.