应激性生活事件与女性抑郁症的关联研究

目的 探讨应激性生活事件(SLEs)与女性复发性重度抑郁症(MDD)的关系.方法 采用16项应激性生活事件量表、神经质量表对符合美国疾病统计手册第四版(DSM-Ⅵ)中单项抑郁障碍诊断标准,具有>2次抑郁发作的单相抑郁症患者(464例)及对照组(689例)进行问卷调查.进行多元logistic回归,调整混杂因素,得出SLEs对抑郁症发病风险的独立效应.结果 通过多元回归分析调整年龄、教育水平、职业、社会地位、婚姻状况的影响后,发现任一SLE与MDD无正相关性(OR=1.15,95%CI=0.87~1.52),16项SLEs中有5项SLE与MDD存在正相关性.而加入神经质量表评分这一变量后,16项SLEs中仅剩2项与MDD存在正相关性.结论 某些SLEs会增加抑郁症的发病风险.神经质水平会影响SLEs对重度抑郁症的作用.

Objective To explore the relationship between lifetime stressful life events(SLEs)and the onset of major depressive disorder(MDD).Methods 464 patients who fulfilled DSM-IV criteria for recurrent major depression and 689 controls were included in the study.Sixteen lifetime stressful life events and neuroticism scale were assessed at personal interview.Odds Ratios(ORs)were calculated by logistic regression.Results After adjusting potential confbunders(age,social class,marital status,occupation,education),we found any stressful life events was not associated with MDD(OR=1.15,95% CI=0.87-1.52).Only five of the sixteen stressful life events(SLEs)were associated with MDD.Then after adding neuroticism as another confbunder,only two stressful life events were associated with MDD.Conclusion Some stressful life events are risk factors for major depression.However high levels of neuroticism will affect the relationship between stressful life events and major depression.