甲状旁腺自荧光显影技术应用研究

A review of autofluorescence imaging of the parathyroid gland

甲状旁腺损伤引起的暂时性和永久性功能减退目前仍不可避免。近年发现甲状旁腺含特有的荧光物质,机制未明。目前在甲状旁腺实时定位中可以使用两种自体荧光探查设备(Fluobeam影像系统、PTeye纤维探针接触式系统),用于甲状旁腺的术中定位和保护。在切除标本中挽救性检出甲状旁腺是该技术的优势,甲状旁腺和甲状腺自体荧光强度比值分别是1.23~7.71。甲状腺术中自体荧光甲状旁腺探查比例76.3%~98.0%,在甲状旁腺术中探查准确性达到90.5%~99.0%。甲状旁腺的自体荧光技术非侵入性,优点是准确实时费时少,不使用染料作对比剂。

The temporary and permanent dysfunction caused by parathyroid injury are inevitable.The parathyroid contains a special fluorescent substance,although its mechanism is not clear.At present,two kinds of autofluorescence detection equipment(FLUOBEAM?imaging system,PTeye fiber probe contact system)can be used for real-time localization of the parathyroid gland for intraoperative localization and protection.The major advantage of this technique is that is allows detection of the parathyroid in excised specimens.The ratios of autofluorescence intensities of the parathyroid and thyroid are 1.23 and 7.71,respectively.The proportion of autofluorescence parathyroid identification sensitivity was 76.3-98.0%and the accuracy was 90.5-99.0%.The parathyroid gland autofluorescence technique is non-invasive,less time-consuming,provides accurate real-time information,and does not use dye as a contrast agent.