西藏高原地区铁过载患者铁调素的水平变化

Change of Hepcidin in Patients with Iron Overload at the Tibet Plateau

目的:检测西藏高原成年藏族男性的血浆铁调素水平,探讨引起铁过载的可能病因。方法:筛选从2017年1月-2018年12月于我科住院治疗的成年藏族男性患者共81例,分为铁过载和非铁过载2组,检测患者血清铁蛋白、血清铁、总铁结合力、血红蛋白、HBSAg、ALT、AST、白蛋白、血肌酐、铁调素,统计分析组间差异,使用回归分析法分析各项指标与铁调素的相关性。结果:铁过载组的血浆铁调素显著高于非铁过载组[93.69(65.57-133.92)ng/ml vs 63.93(40.01-90.65)ng/ml](P=0.005)。应用回归分析发现,铁调素与铁蛋白(β=0.03ng/ml,95%CI 0.01-0.05)(P=0.0010)、BMI(β=5.71 ng/ml,95%CI 0.54-10.88)(P=0.0338)呈正相关。结论:西藏高原的藏族成年男性患铁过载并不是由于体内铁调素缺乏引起的,西藏高原藏族人群的铁代谢紊乱可能与代谢综合征有关。

Objective:To explore the possible etiological factors of iron overload through detecting plasma hepcidin level of adult males at Tibet plateau.Methods:81 Tibetan male adult patients hospitalized in our department during January 2017-December 2018 were selected,and divided into iron overload group and non-iron overload group.The difference in serum ferritin,serum iron,total iron binding capacity,hemoglobin,HBSAg,ALT,AST,albumin,creatinine and hepcidin of patients in each group were tested.To analyze the differences between groups.The regression analysis was applied to analyze the relationship between laboratory index and hepcidin.Results:The plasma hepcidin of iron overload group was significantly higher than that of the non-iron overload group[93.69(65.57-133.92)ng/ml vs 63.93(40.01-90.65)ng/ml](P=0.005).And there was a positive correlation between plasma hepcidin and ferritin(β=0.03 ng/ml,95%CI 0.01-0.05)(P<0.01)and BMI(β=5.71 ng/ml,95%CI 0.54-10.88)(P<0.05).Conclusion:Iron overload at Tibet plateau can not be attributed to hepcidin deficiency in Tibetan adult male patients.Iron metabolism disorders in Tibetan population may be associated with metabolic syndrome.