醒脾养儿汤联合葛根芩连散脐部贴敷治疗小儿轮状病毒肠炎临床研究

Clinical Study of Applying Xingpi Yang'er Decoction Combined with Gegen Linglian Powder Umbilical Cord Application in the Treatment of Children with Rotavirus Enteritis

目的:观察醒脾养儿汤联合葛根芩连散脐部贴敷治疗小儿轮状病毒肠炎临床疗效。方法:研究共计纳入100例轮状病毒肠炎患儿,患儿均由我院2017年2月~2019年1月收治,采取随机数字表法将患儿分为观察组与对照组,予以对照组患儿(50例)临床西医常规治疗,观察组患儿(50例)在对照组治疗基础上联合醒脾养儿汤及葛根芩连散脐部贴敷治疗,比较两组患儿临床治疗效果、患儿止泻、止吐、脱水纠正及住院时间、治疗3天后患儿大便轮状病毒抗原检测结果、治疗前后患儿肠道微生态(乳杆菌、肠杆菌、双歧杆菌)变化情况及炎症因子{白介素6(IL-6)、肿瘤坏死因子α(TNF-α)}变化情况、治疗前后心肌酶谱指标变化情况、治疗不良反应情况。结果:观察组患儿治疗有效率(96.00%)高于对照组(84.00%),P<0.05;观察组患儿治疗后止泻、止吐、脱水纠正及住院时间短于对照组,P<0.05;治疗3天后,观察组患儿大便轮状病毒抗原转阴率高于对照组,P<0.05;治疗前,两组患儿肠道微生态乳杆菌、肠杆菌、双歧杆菌及IL-6、TNF-α炎性因子均相当,P>0.05,治疗后各组患儿肠道微生态乳杆菌、肠杆菌、双歧杆菌及IL-6、TNF-α炎性因子水平改善,观察组优于对照组,P<0.05;治疗前两组患儿心肌酶谱指标肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)水平相当,P>0.05,治疗后各组患儿CK、CK-MB、LDH水平均下降,观察组低于对照组,P<0.01;观察组与对照组患儿治疗不良反应率均较低,P>0.05。结论:醒脾养儿汤联合葛根芩连散脐部贴敷治疗小儿轮状病毒肠炎具有较高临床价值,患儿疗效提升,症状改善,恢复好,且不良反应少,安全性高,值得推广与应用。

Objective:To explore the clinical value of applying Xingpi Yang'er Decoction combined with Gegen Linglian Powder in the treatment of rotavirus enteritis in children.Methods:Studied a total of 100cases of children with rotavirus enteritis,children all by our hospital from February 2017to January 2019were to take the children with random number table method divided into observation group and controlled group,to the controled group(50cases)in children with clinical routine western medicine treatment,the observation group of patients in the controlled group(50cases)treatment on the basis of joint amuse oneself own soup and Gegen Linglian powder even scattered navel stick apply treatment.Compared the two groups of children with clinical treatment,children with antidiarrheal,check correction and length of hospital stay,vomiting,dehydration,stool rotavirus antigen after treatment for 3d detection results,before and after treatment with intestinal micro ecology(lactobacillus,e.coli and bifidobacteria)and the changes of inflammatory cytokines{interleukin 6(IL-6),tumor necrosis factor alpha(TNF-alpha)}changes,changes in myocardial enzyme indexes before and after treatment,treatment of adverse reactions.Results:The effective rate of treatment in the observation group(96.00%)was higher than that in the controlled group(84.00%),P<0.05.After treatment,the duration of diarrhea,vomiting,dehydration and hospitalization in the observation group was shorter than that in the controlled group(P<0.05).After 3d treatment,the negative rate of fecal rotavirus antigen in the observation group was higher than that in the controlled group(P<0.05).Before treatment,the intestinal microectobacillus,enterobacter,bifidobacteria and il-6 and tnf-alpha inflammatory factors in the two groups were all the same,with P>0.05.After treatment,the levels of intestinal microectobacillus,enterobacter,bifidobacteria and IL-6 and tnf-alpha inflammatory factors in the two groups were improved,and the observation group was superior to the controlled group,with P<0.05.Before treatment,the levels of creatine kinase(CK),creatine kinase isoenzyme(ck-mb)and lactate dehydrogenase(LDH)in the two groups were similar(P>0.05).After treatment,the levels of CK,CK-MB and LDH in the two groups were decreased(P<0.01).The rate of adverse reactions was lower in the observation group and the controlled group(P>0.05).Conclusion:Xingpi Yang'er Decoction combined with Gegen Linglian Powder umbilical cord application has a higher clinical value in the treatment of rotavirus enteritis in children,with improved curative effect,improved symptoms and good recovery,and less adverse reactions,high safety,worthy of promotion and application.