血清NSE、叶酸水平与老年继发性肌张力障碍的相关性

Correlation between Serum NSE,Folic Acid Levels and Senile Secondary Dystonia

目的分析血清NSE、叶酸水平与老年继发性肌张力障碍的相关性。方法选择2017年3月~2019年8月于新疆维吾尔自治区人民医院住院治疗老年患者1017例,检测患者入院时血清NSE、叶酸水平,住院治疗后随访3个月,期间发生继发性肌张力障碍患者纳入患病组,其他则纳入对照组,比较两组入院时血清NSE与叶酸水平,观察各血清水平预测疾病发生的价值。结果全部患者中发生继发性肌张力障碍81例,发生率为7.96%;患病组血清NSE高于对照组,叶酸水平低于对照组,差异有统计学意义(P<0.05);血清NSE水平过表达、叶酸缺乏与老年继发性肌张力障碍发生相关,可能是疾病发生的影响因素(P<0.05);绘制ROC曲线,血清NSE、叶酸预测老年继发性肌张力障碍的曲线下面积(AUC)分别为0.966.0.910,预测价值高。结论老年患者入院时血清NSE过表达、叶酸缺乏可能预示继发性肌张力障碍高风险,入院时监测其血清NSE、叶酸水平,对早期预测继发性肌张力障碍发生有较高的临床价值。

Objective To analyze the correlation between serum neuron-specific enolase(NSE),folic acid levels and senile secondary dystonia.Methods Totally 1017 senile patients who hospitalized in the people's hospital of Xinjiang Uygur Autonomous Region from March 2017 to August 2019 were selected.The levels of serum NSE and folic acid of the patients were detected on admission,and they were given 3 months of follow-up after hospitalization.The patients with secondary dystonia during follow-up were included in the disease group,and the others were included in the control group.The levels of serum NSE and folic acid on admission were compared between two groups.The value of each serum level in predicting the incidence of disease was observed.Results Totally 81 cases of secondary dystonia occurred in the all patients,and the incidence was 7.96%.The level of serum NSE in the disease group was higher than that in the control group,and the level of folic acid in the disease group was lower than that in the control group,and the difference was statistically significant(P<0.05).The over-expression of serum NSE and folic acid deficiency were related to the occurrence of senile secondary dystonia,which may be the influencing factors of the disease(P<0.05).The ROC curve was drawn,and the areas under the curve(AUC)of serum NSE and folic acid in predicting senile secondary dystonia were 0.966 and 0.910,respectively,which had high predictive value.Conclusion The over-expression of serum NSE and folic acid deficiency in senile patients on admission may indicate the high risk of secondary dystonia.The monitoring of serum NSE and folic acid levels on admission has higher clinical value in early prediction of the occurrence of secondary dystonia.