膳食干预对肥胖型多囊卵巢综合征患者的影响

Effects of Dietary Intervention on Metabolic Level and Pregnancy Rate in Patients with Obesity Polycystic Ovary Syndrome

目的探讨膳食干预对肥胖型多囊卵巢综合征患者代谢水平和受孕率的影响。方法选取2019年1月~2019年6月就诊的肥胖型多囊卵巢综合征且有生育需求的80例患者为研究对象,随机分为试验组和对照组(每组40例)。干预组给子二甲双胍和膳食干预,对照组只进行二甲双胍治疗。在干预实施前和实施12周后对所有患者进行体格检查和实验室检测,并记录患者在治疗期间内的排卵成功人数和受孕成功人数。结果干预12周后,试验组患者BMI明显降低且低于对照组(1=3.80,.P<0.05),FBG、FINS和HOMA-IR水平明显低于对照组(t=3.30.2.32.2.49,P<0.05),TC.TC和LDL-C水平明显低于对照组(t2.98.3.59.2.61,P<0.05),FSH,LH.E,和T水平明显低于对照组(t=4.10.5.03.3.96.5.39,P<0.05),排卵成功率和受孕成功率均高于对照组.差异有统计学意义(χ^2=4.89.3.89,P<0.05)。结论膳食干预可以明显改善其糖脂代谢及性激素水平,提高患者的排卵成功率和受孕成功率。

Objective To investigate the effect of dietary intervention on metabolic level and conception rate in patients with obese polycystic ovary syndrome.Methods A total of 80 patients with obesity polycystic ovary syndrome and fertility needs were selected from January 2019 to June 2019.They were randomly divided into experimental group and control group(40 patients in each group).The pa・tients in the intervention group were given metformin and dietary intervention,while those in the control group were only treated with metformin.Physical examinations and laboratory tests were performed on all patients before and 12 weeks after the intervention was implemented,and the number of successful ovulation and successful pregnancy during the treatment period were recorded.Results After 12 weeks of intervention,the BMI of the patients in the experimental group was significantly lower than that in the control group(Z=3.80,P<0.05),and the levels of FBG,FINS and HOMA-1R were significantly lower than those in the control group(t=3.30,2.32,2.49,P<0.05),TG,TC and LDL-C levels were significantly lower than those in the control group(t=2.98,3.59,2.61,P V 0.05),FSH,LH,E2 and T levels were significantly lower than those in the control group(t=4.10,5.03,3.96,5.39,P<0.05),the ovulation success rate and pregnancy success rate were higher than the control group,the difference was statistically significant(χ^2=4.89,3.89,P<0.05).Conclusion Dietary intervention can significantly improve glucose and lipid metabolism and sex hormone levels of patients with obesity polycystic ovary syndrome,and increase the success rate of ovulation and pregnancy of patients.