绝经后医务人员骨密度与椎体骨折的横向研究

Cross-sectional study of bone mineral density and vertebral fracture in the medical postmenopausal women with a single center in Guangzhou

目的通过横向研究探讨绝经后医务人员骨密度与椎体骨折的相互关系。方法从单中心医务人员中,随机抽取216名绝经后女性,通过双能X线吸光测定仪检测其骨密度,运用Genant半定量法评估椎体骨折,分析骨密度与骨质疏松性骨折、椎体骨折的畸形程度以及EQ-5D评分的关系。结果绝经后医务人员椎体骨密度的正常组、骨量减少组及骨质疏松组分别占27%、35%、38%;随着骨密度T值的降低,正常组(T≥-1.0)、骨量减少组(-2.5<T<-1.0)和骨质疏松组(T≤-2.5)的椎体骨质疏松性骨折患病率明显升高(P<0.05),分别为28%、42%和53%;椎体骨折组(无论有/无临床症状)的骨密度明显低于无骨折组(P<0.01);椎体骨折畸形程度越重,其骨密度越低(P<0.01),躯体伸展程度、日常活动、疼痛或舒适度的EQ-5D评分亦越低(P<0.05)。结论绝经后医务人员随着骨密度的降低,骨质疏松和椎体骨折的患病率增加,生活质量亦降低。

Objective To analyze the relationship between bone mineral density(BMD)and vertebral fracture in the medical postmenopausal women through a cross-sectional study.Methods A total of 216 postmenopausal women from the medical staff in a single center was entered randomly.The measurement for BMD was used by dual energy X-ray absorptiometry.Vertebral fracture was evaluated by a semi-quantitative method using the Genant,s method.The relationship between BMD and osteoporotic fracture,a degree of deformity in vertebral fracture and EQ-5D was analyzed.Results The distribution of the normal,osteopenia and osteoporosis group in the medical postmenopausal women were 27%,35%and 38%.The prevalence of the normal(T≥-1.0),osteopenia(-2.5<T<-1.0)and osteoporosis(T≤-2.5)group were decrease significantly with the T-scores increases(P<0.05);They were 28%,42%and 53%respectively.BMD in subjects with symptomatic or asymptomatic vertebral fracture were significantly lower than those without fracture(P<0.01).The BMD was significantly lower with more severe degree of deformity in vertebral fracture(P<0.01)and lower scores in mobility,usual activities and pain/discomfort of the EQ-5D(P<0.05).Conclusion In the medical postmenopausal women,the prevalence of osteoporosis and vertebral fracture increase and quality of life decrease with lower BMD.