绝经后中国女性跟骨定量超声和双能X线检查骨质疏松症的对比研究

Comparison of the examination between dual-energy X-ray absorptiometry(DXA)and calcaneal quantitative ultrasound(QUS)on osteoporosis in Chinese postmenopausal women

目的观察绝经后中国女性跟骨定量超声和双能X线检查骨质疏松症的效果比较。方法评估234名绝经后未接受过治疗的40~80岁女性的腰椎、双侧股骨颈和全髋关节部位的骨密度(bone mineral density,BMD)的DXA参数和左右跟骨的QUS参数。计算BMD和QUS参数的相关系数。生成接收器操作特性曲线,并评估曲线下面积(area under curve,AUC)来定义QUS的截止值。结果跟骨QUS能够识别右侧髋关节(AUC,0.887)和左股骨颈(AUC,0.824)的T值为-2.5或更低的绝经后妇女。为了筛选目的,定义了右侧(1.455)和左侧(1.480)跟骨的QUS T值的截止值。结论与DXA这种标准的诊断方法相比,可以推荐QUS作为预筛选工具来减少DXA筛查的数量。

Objective To compare the efficacy between dual-energy X-ray absorptiometry(DXA) and calcaneal quantitative ultrasound(QUS) examination on osteoporosis in Chinese postmenopausal women.Methods We assessed BMD at the lumbar spine,bilateral femoral neck,and total hip sites with DXA and QUS parameters of the right and left calcanei in a cohort of 234 postmenopausal treatment-naive women of 40-80 years old.The correlation coefficients between BMD and QUS parameters were calculated.Receiver operating characteristic curves were generated and areas under the curves(AUCs) were evaluated.Cutoff values for QUS were defined.Results Calcaneal QUS was capable to identify postmenopausal women with a T score of minus 2.5 or lower at the right hip(AUC,0.887) and the left femoral neck(AUC,0.824).Cutoff values for the QUS T scores at the right(1.455) and left(1.480) calcanei were defined for screening purposes.Conclusion Considering the diagnostic accuracy in comparison to DXA,QUS can be recommended as a prescreening tool to reduce the number of DXA screening.