超声弹性成像技术对乳腺癌的诊断价值及其征象与乳腺癌ER等受体的相关性

The Analysis of Diagnostic Value and Correlation of Molecular Markers of Breast Cancer with UE

目的探讨超声弹性成像技术对乳腺癌的诊断价值及其征象与乳腺癌ER等受体的相关性。方法选取120例乳腺疾病患者(单病灶)(均经术后病理确诊),同时给予常规超声及UE检查,比较2种超声方式在诊断乳腺癌方面的差异情况。分析UE征象与乳腺癌ER等受体的相关性。结果恶性肿块患者形态不规则、微钙化、肿块后方回声衰减、边缘模糊或毛刺等图像特征均明显高于良性肿块患者(P<0.05)。常规超声诊断乳腺良性肿块及恶性肿块的符合率为81.3%及72.5%,而超声弹性成像诊断乳腺良性肿块及恶性肿块的符合率为92.5%和90.0%,均有统计学差异(P<0.05);常规超声诊断敏感度、特异度及准确率分别为72.5%、81.3%和78.3%,超声弹性成像诊断敏感度、特异度及准确率分别为90.0%、92.5%和91.7%,均有统计学差异(P<0.05)。经分析发现乳腺癌ER受体阳性表达情况与乳腺恶性肿瘤的形态、边界相关,PR受体阳性表达情况与乳腺恶性肿瘤的大小、边缘及边界相关,而Her-2阳性表达情况与乳腺恶性肿瘤的形态、边缘、边界及腋窝淋巴结转移相关,均有统计学差异(P<0.05)。结论UE对乳腺癌的鉴别诊断临床价值显著优于常规超声检查,同时乳腺癌的分子标志物与其UE的超声征象存在一定的相关性,此可为乳腺癌的诊疗提供一定的参考价值。

Objective To investigate the the analysis of diagnostic value and correlation of molecular markers of breast cancer with UE.Methods To screening 120 cases of patients with mastopathy as research subjects,and all patients use conventional ultrasonic and UE examnations,then comparing in terms of the iconography signmcance and so on.Results The ultrasonic signs in breast benign disease was different from breast malignancy disease(P<0.05);The conventional ultrasound had diagnostic coincidence rates of 81.3%and 72.5%in breast benign disease and breast cancer respectively.In contrast,ultrasonic elastography had the diagnostic coincidence rate of 92.5%and 90.0%in the breast benign disease and breast cancer,with statistically significant difference(P<0.05).The diagnostic sensitivity,specificity and accuracy rate of conventional ultrasound were72.5%、81.3%and 78.3%respectively,while those of ultrasonic elastography were 90.0%、92.5%and 91.7%,with statistically significant difference(P<0.05);The ultrasonic signs had some relationship with the molecular markers of breast cancer(P<0.05).Conclusion Ultrasound elasticity imaging can effectively identify benign and malignant breast masses,and the ultrasonic signs had some relationship with the molecular markers of breast cancer.