摘要
肩袖(rotator cuff,RC)肌腱损伤是肩关节急慢性疼痛、活动度受限的主要原因,急性损伤全层撕裂时通常需要进行外科手术的及时干预。临床上RC损伤的修复难点在于骨-肌腱界面的重建,虽然目前已经建立了多种手术创伤诱导性肩袖损伤动物模型,但仍缺乏合适的动物模型以及确切的治疗方法。本文将对国内外RC肌腱损伤诱导性动物模型的建立方法及适用范围进行总结归纳,探讨动物模型的选择及功能评估方法,以期为RC损伤的基础科研提供相应的理论依据。
Rotator cuff tendon injury is the main cause of acute and chronic shoulder pain and a limited range of motion. Surgical intervention is usually needed in cases of acute injury with full-thickness tears. The difficulty in repairing rotator cuff injuries lies in reconstructing the bone-tendon interface. Although various animal models of rotator cuff injuries induced by surgical trauma have been developed,suitable animal models and exact treatment method are lacking. This paper summarizes the establishment method and applicable scope of rotator cuff tendon injury-induced animal models and explores the selection of animal models and functional evaluation method to provide a corresponding theoretical basis for basic scientific research on rotator cuff injuries.
作者
许博洋
庞小娟
曾禹铭
周严冬
郭义
XU Boyang;PANG Xiaojuan;ZENG Yuming;ZHOU Yandong;GUO Yi(College of Acupuncture and Massage,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;School of Integrative Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617;School of Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617;Research Center of Experimental Acupuncture Science,Tianjin University of Traditional Chinese Medicine,Tianjin 301617;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2020年第4期545-550,共6页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然科学基金重点项目(81330088)
国家级大学生创新创业训练项目(201910063002)。
关键词
肩关节
肩袖肌腱损伤
动物模型
组织构建
软组织生物力学
shoulder joint
rotator cuff injury
animal model
tissue construction
soft tissue biomechanics