肩袖肌腱损伤诱导性动物模型构建评价及研究进展

Evaluation and progress of the construction of a rotator cuff tendon injury-induced animal model

肩袖(rotator cuff,RC)肌腱损伤是肩关节急慢性疼痛、活动度受限的主要原因,急性损伤全层撕裂时通常需要进行外科手术的及时干预。临床上RC损伤的修复难点在于骨-肌腱界面的重建,虽然目前已经建立了多种手术创伤诱导性肩袖损伤动物模型,但仍缺乏合适的动物模型以及确切的治疗方法。本文将对国内外RC肌腱损伤诱导性动物模型的建立方法及适用范围进行总结归纳,探讨动物模型的选择及功能评估方法,以期为RC损伤的基础科研提供相应的理论依据。

Rotator cuff tendon injury is the main cause of acute and chronic shoulder pain and a limited range of motion. Surgical intervention is usually needed in cases of acute injury with full-thickness tears. The difficulty in repairing rotator cuff injuries lies in reconstructing the bone-tendon interface. Although various animal models of rotator cuff injuries induced by surgical trauma have been developed,suitable animal models and exact treatment method are lacking. This paper summarizes the establishment method and applicable scope of rotator cuff tendon injury-induced animal models and explores the selection of animal models and functional evaluation method to provide a corresponding theoretical basis for basic scientific research on rotator cuff injuries.