妊娠期甲亢孕妇血清甲状腺功能与免疫含量变化及其临床意义分析

Changes of serum thyroid function and immune content in pregnant women with hyperthyroidism and their clinical significance

目的探究妊娠期甲亢孕妇血清甲状腺功能与免疫含量变化及其临床意义。方法选取2017年1月至2017年12月本院收治的妊娠期合并甲亢孕妇80例作为研究组,选取同期本院收治的妊娠但未合并甲亢孕妇80名作为对照组。比较两组孕妇妊娠早、中及晚期血清免疫功能以及甲状腺功能。结果妊娠早期,研究组TRAb阳性率、T3、T4水平均高于对照组(P<0.05),两组孕妇TSH、FT3、FT4水平比较差异无统计学意义;妊娠中期,研究组TRAb阳性率、T3、T4水平均高于对照组(P<0.05),FT3、FT4水平明显低于对照组(P<0.05),两组孕妇TSH水平比较差异无统计学意义;妊娠晚期,研究组孕妇FT3、FT4水平明显高于对照组(P<0.05),FT3、FT4水平明显低于对照组(P<0.05),两组孕妇TRAb阳性率、TSH水平比较差异无统计学意义。结论妊娠期甲亢孕妇的血清甲状腺功能与甲状腺免疫含量在妊娠的早、中及晚期均存在明显差异,应注重对T3、T4以及TRAb水平的检测,从而为临床诊断提供有效的理论依据。

Objective To explore the changes of serum thyroid function and immune content in pregnant women with hyperthyroidism during pregnancy and its clinical significance.Methods From January 2017 to December 2017,80 pregnant women with hyperthyroidism who were admitted to our hospital during pregnancy were selected as the study group,and 80 pregnant women without hyperthyroidism who were admitted to our hospital during the same period were selected as the control group.Serum immune function and thyroid function in the early,middle and late stages of pregnancy were compared between the two groups.Results In early stage of pregnancy,the TRAb positive rate,T3 and T4 levels in the study group were higher than those in the control group(P<0.05).There was no statistically significant difference in TSH,FT3 and FT4 levels between the two groups.In middle stage of pregnancy,the positive rate of TRAb,T3 and T4 in the study group were higher than those in the control group(P<0.05),and the levels of FT3 and FT4were significantly lower than those in the control group(P<0.05).In late stage of pregnancy,the FT3 and FT4 levels of pregnant women in the study group were significantly higher than those in the control group(P<0.05),and the FT3 and FT4 levels were significantly lower than those in the control group(P<0.05).There was no statistically significant difference in the TRAb positive rate and TSH level between the two groups.Conclusion Serum thyroid function and thyroid immune content of pregnant women with hyperthyroidism in pregnancy are significantly different in the early,middle and late stages of pregnancy,so attention should be paid to the detection of T3,T4 and TRAb levels,so as to provide an effective theoretical basis for clinical diagnosis.