四川阿坝藏族儿童结核发病与维生素D水平相关性研究

Study on the relationship between tuberculosis incidence and vitamin D level in Tibetan children in Aba

目的探讨四川省阿坝地区藏族儿童结核发病与维生素D水平的相关性。方法将2017年1月—2019年9月收治的63名肺结核病患儿,以及同时期儿童保健门诊就诊的145例健康儿童作为研究对象。分别收集2组性别、年龄、居住环境(通风、光照)及BMI值,采集空腹血检测维生素D水平。观察2组儿童维生素D水平,分析维生素D水平与结核患病的相关因素。结果结核组平均维生素D水平为(12.08±4.79)ng/mL,儿保组平均维生素D水平为(22.37±7.10)ng/mL,差异有统计学意义(P<0.05);Pearson分析结果显示,维生素D水平与结核患病呈负相关(P<0.05)。结论儿童结核发病与维生素D水平存在一定的相关性,维生素D水平是结核病的保护性因素。

Objective To investigate the correlation between tuberculosis incidence and vitamin D levels in Tibetan children in Aba area,Sichuan Province.Methods The clinical data of 63 children with tuberculosis treated in Aba area people's hospital from January 2017 to September 2019 were randomly selected,and the data of 145 children's health care in Aba area were randomly selected.Tuberculosis group(n=63):Statistics of patients'gender,age,living environment(ventilation,light)and BMI values were collected,anti-TB treatment was standardized,and fasting blood was drawn the next morning after admission to check the vitamin D levels of children.Childcare group(n=145):statistics of children's gender,age,living environment(ventilation,light)and BMI values,and fasting blood to check vitamin D levels.Observation indicators:Comparison of vitamin D levels in children of the two groups and correlation analysis between vitamin D levels and tuberculosis.Results The average vitamin level in the tuberculosis group was(12.08±4.79)ng/mL,and the average vitamin level in the childcare group was(22.37±7.10)ng/mL.The results of the comparison between the two groups were P<0.05.Pearson linear analysis of vitamin level and tuberculosis was performed(P<0.05).Pearson linear analysis of vitamin level and tuberculosis was performed,P<0.05,the difference was statistically significant,which proved that vitamin level was negatively correlated with tuberculosis.Conclusion There is a certain correlation between the incidence of tuberculosis in children and the level of vitamin D,which is the protective factor of tuberculosis.