局部晚期宫颈癌预后因素研究进展

Research progress of prognostic factors in locally advanced cervical cancer

宫颈癌是全世界常见的女性恶性肿瘤之一,且早期可无症状,以致于大部分患者就诊时已是中晚期(根据FIGO分期为IB2~IV期)。指南推荐局部晚期宫颈癌(LACC)患者治疗方案首选同步放化疗,虽近期疗效尚可,但长期大量的随访数据表明远期预后差,易出现复发和转移。对LACC患者的预后因素进行分析研究,有利于根据患者的具体情况制定最佳个体化治疗方案,对提高LACC患者生存率及生活质量有重要意义。本文从年龄、是否有人类乳头瘤病毒(HPV)感染史、血红蛋白指标、肿瘤分期及分化程度、治疗方式等方面进行综述。

Cervical cancer is one of the most common malignant tumors in women all over the world.It can be asymptomatic at the early stage,therefore,most patients are in the middle and advanced stages(in phase IB2-IV by FIGO stages)at the time of consultation.The first choice of synchronous radiotherapy and chemotherapy is recommended by guidelines for patients with locally advanced cervical cancer(LACC).Although the short-term efficacy is fair,numerous long-term follow-up data indicate that the long-term prognosis is poor and it is prone to recurrence and metastasis.Analytical investigation on the prognostic factors of LACC patients contributes to making the best individualized treatment plan according to the specific conditions of patients.It is of great significance to improve the survival rate and quality of life of patients with LACC.This paper offers an overview of age,history of human papillomavirus(HPV)infection,hemoglobin index,tumor stages and differentiation,and treatment modes,etc.