尿毒清颗粒结合非布司他治疗高尿酸血症的效果

Effect of Niaoduqing Granules combined with Febuxostat in the treatment of hyperuricemia

目的探讨尿毒清颗粒结合非布司他治疗高尿酸血症(HUA)的临床效果。方法选取2018年6月~2019年9月于我院就诊的40例HUA患者作为研究对象,按照随机数字表法将其分为对照组和观察组,每组各20例。对照组患者采用非布司他治疗,研究组患者采用非布司他结合尿毒清颗粒治疗。观察两组患者的临床疗效、实验室相关指标、生活质量、不良反应发生情况。结果观察组患者的治疗总有效率(95.00%)高于对照组(75.00%),差异有统计学意义(P<0.05)。治疗后,观察组患者的血肌酐、血尿酸、随机尿清蛋白值、胱抑素C浓度低于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后的生活质量(SF-12)量表各项评分高于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论尿毒清颗粒结合非布司他治疗HUA的临床效果显著,安全性良好,可有效控制因该病而改变的各项指标,改善患者肾功能,提高生活质量。

Objective To explore the clinical effect of Niaoduqing Granules combined with Febuxostat in the treatment of hyperuricemia(HUA).Methods Forty HUA patients who treated in our hospital from June 2018 to September 2019 were selected as the research objects,and were divided into control group and observation group according to the random number table method,20 cases in each group.The control group was treated with Febuxostat,and the observation group was treated with Niaoduqing Granules combined with Febuxostat.The clinical efficacy,laboratory-related indicators,quality of life,and adverse reactions of the two groups were observed.Results The total effective rate of the observation group(95.00%)was higher than that of the control group(75.00%),the difference was statistically significant(P<0.05).After treatment,serum creatinine,serumuricacid,random urinary albumin,cystatin C concentration in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The scores of the quality of life(SF-12)scale after treatment in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusions Niaoduqing Granules combined with Febuxostat has significant clinical efficacy and good safety.It can effectively control various indicators that change due to the disease and Improve quality of life.